Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1633022..1633244 Replicon chromosome
Accession NZ_CP014348
Organism Escherichia coli str. K-12 substr. MG1655 strain JW5437-1

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag AWN69_RS08055 Protein ID WP_000141634.1
Coordinates 1633137..1633244 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1633022..1633088 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWN69_RS08030 1628463..1629365 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
AWN69_RS08035 1629376..1630359 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
AWN69_RS08040 1630356..1631360 + 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
AWN69_RS08045 1631390..1632661 - 1272 WP_001295225.1 transporter -
- 1633022..1633088 - 67 - - Antitoxin
AWN69_RS08055 1633137..1633244 + 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
AWN69_RS08060 1633331..1635010 - 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
AWN69_RS08065 1635007..1635198 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
AWN69_RS08070 1635195..1636766 - 1572 WP_001204931.1 cellulose biosynthesis protein BcsE -
AWN69_RS08075 1637039..1637227 + 189 WP_001063318.1 YhjR family protein -
AWN69_RS08080 1637239..1637991 + 753 Protein_1526 cellulose biosynthesis protein BcsQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T60760 WP_000141634.1 NZ_CP014348:1633137-1633244 [Escherichia coli str. K-12 substr. MG1655]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T60760 NZ_CP014348:1633137-1633244 [Escherichia coli str. K-12 substr. MG1655]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT60760 NZ_CP014348:c1633088-1633022 [Escherichia coli str. K-12 substr. MG1655]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References