Detailed information of TA system TA060746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1700986..1701498
• Replicon: chromosome
• Accession: NZ_CP014326
• Organism: Streptococcus mitis strain SVGS_061

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A110A1Y2
• Locus tag: AXK38_RS08005
• Protein ID: WP_061088336.1
• Coordinates: 1700986..1701240 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: AXK38_RS08010
• Protein ID: WP_173425167.1
• Coordinates: 1701244..1701498 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXK38_RS07990	1698067..1698381	-	315	WP_000979235.1	DNA-directed RNA polymerase subunit omega	-
AXK38_RS07995	1698406..1699032	-	627	WP_000775041.1	guanylate kinase	-
AXK38_RS08000	1699170..1700783	-	1614	WP_061088335.1	ribonuclease Y	-
AXK38_RS08005	1700986..1701240	-	255	WP_061088336.1	Txe/YoeB family addiction module toxin	Toxin
AXK38_RS08010	1701244..1701498	-	255	WP_173425167.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AXK38_RS08015	1701734..1702831	-	1098	WP_061088337.1	nucleotidyltransferase	-
AXK38_RS08020	1702841..1703587	-	747	WP_081097404.1	class I SAM-dependent methyltransferase	-
AXK38_RS08025	1703691..1704044	-	354	WP_061088338.1	ribosome silencing factor	-
AXK38_RS08030	1704045..1704638	-	594	WP_061088339.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
AXK38_RS08035	1704638..1705267	-	630	WP_061088340.1	nicotinate-nucleotide adenylyltransferase	-
AXK38_RS08040	1705319..1705630	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10147.65 Da
• Isoelectric Point: 6.9740

>T60746 WP_061088336.1 NZ_CP014326:c1701240-1700986 [Streptococcus mitis]
MLLKFTEDAWVDYCYWQTQDKKTLKRINMLIKDIQRDPFVGIGKPEPLKYDYQGAWSRRIDSENRLIYMMDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T60746 NZ_CP014326:c1701240-1700986 [Streptococcus mitis]
ATGTTGCTCAAGTTTACAGAGGATGCCTGGGTGGATTATTGCTACTGGCAAACTCAAGACAAGAAAACGTTAAAAAGAAT
TAACATGCTAATCAAGGATATTCAACGCGATCCTTTTGTAGGAATTGGTAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCCTGGTCTCGTCGCATTGACTCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCTTTC
AAAGATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9738.06 Da
• Isoelectric Point: 4.8430

>AT60746 WP_173425167.1 NZ_CP014326:c1701498-1701244 [Streptococcus mitis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
MIEE

Nucleotide

• Length: 255 bp

>AT60746 NZ_CP014326:c1701498-1701244 [Streptococcus mitis]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATTCAAGAAACCCTGA
GAATTGCTCAAAATAAAGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGGTACAT
ATGATTGAGGAGTAA

Structures

Toxin

• AlphaFold DB: A0A110A1Y2