Detailed information of TA system TA060684

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4947382..4947603
• Replicon: chromosome
• Accession: NZ_CP014314
• Organism: Escherichia coli O157:H7 strain JEONG-1266

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: JEONG1266_RS31900
• Protein ID: WP_001295224.1
• Coordinates: 4947496..4947603 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4947382..4947447 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JEONG1266_RS25380	4942822..4943724	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
JEONG1266_RS25385	4943735..4944718	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
JEONG1266_RS25390	4944715..4945719	+	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JEONG1266_RS25395	4945749..4947020	-	1272	WP_001301684.1	amino acid permease	-
-	4947382..4947447	-	66	NuclAT_16	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_16	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_16	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_16	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_21	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_21	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_21	-	Antitoxin
-	4947382..4947447	-	66	NuclAT_21	-	Antitoxin
JEONG1266_RS31900	4947496..4947603	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
JEONG1266_RS25410	4947690..4949369	-	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
JEONG1266_RS25415	4949366..4949557	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JEONG1266_RS25420	4949554..4951125	-	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
JEONG1266_RS25425	4951398..4951586	+	189	WP_001063316.1	YhjR family protein	-
JEONG1266_RS25430	4951598..4951795	+	198	WP_000279508.1	AAA family ATPase	-
JEONG1266_RS25435	4951814..4952350	+	537	WP_001270903.1	cellulose synthase operon protein YhjQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T60684 WP_001295224.1 NZ_CP014314:4947496-4947603 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T60684 NZ_CP014314:4947496-4947603 [Escherichia coli O157:H7]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT60684 NZ_CP014314:c4947447-4947382 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin