Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2523871..2524666 Replicon chromosome
Accession NZ_CP014314
Organism Escherichia coli O157:H7 strain JEONG-1266

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag JEONG1266_RS13585 Protein ID WP_000854914.1
Coordinates 2523871..2524245 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag JEONG1266_RS13590 Protein ID WP_001280954.1
Coordinates 2524292..2524666 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JEONG1266_RS13545 2518875..2519366 - 492 WP_001301587.1 DUF1097 domain-containing protein -
JEONG1266_RS13550 2519468..2520022 - 555 WP_001001917.1 molecular chaperone YcdY -
JEONG1266_RS13555 2520046..2520783 - 738 WP_000283664.1 zinc-binding phosphatase -
JEONG1266_RS13560 2520838..2521776 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
JEONG1266_RS13570 2522247..2523089 - 843 WP_001280481.1 DUF4942 domain-containing protein -
JEONG1266_RS13575 2523174..2523371 - 198 WP_000839282.1 DUF957 domain-containing protein -
JEONG1266_RS13580 2523383..2523874 - 492 WP_000976853.1 hypothetical protein -
JEONG1266_RS13585 2523871..2524245 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
JEONG1266_RS13590 2524292..2524666 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JEONG1266_RS13600 2524829..2525050 - 222 WP_001220314.1 DUF987 domain-containing protein -
JEONG1266_RS13605 2525113..2525589 - 477 WP_001186738.1 RadC family protein -
JEONG1266_RS13610 2525605..2526090 - 486 WP_000214398.1 antirestriction protein -
JEONG1266_RS13615 2526181..2526999 - 819 WP_001234682.1 DUF945 domain-containing protein -
JEONG1266_RS13625 2527339..2528409 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
JEONG1266_RS13630 2528406..2529311 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 2515257..2526090 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T60673 WP_000854914.1 NZ_CP014314:c2524245-2523871 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T60673 NZ_CP014314:c2524245-2523871 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT60673 WP_001280954.1 NZ_CP014314:c2524666-2524292 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT60673 NZ_CP014314:c2524666-2524292 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References