Detailed information of TA system TA060652

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 268819..269519
• Replicon: plasmid unnamed2
• Accession: NZ_CP014309
• Organism: Burkholderia sp. PAMC 26561

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: AXG89_RS28055
• Protein ID: WP_062173683.1
• Coordinates: 268819..269115 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: AXG89_RS28060
• Protein ID: WP_062173681.1
• Coordinates: 269118..269519 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXG89_RS28020	263922..264881	+	960	WP_062174158.1	SOS response-associated peptidase family protein	-
AXG89_RS28025	265005..265406	-	402	WP_069638471.1	hypothetical protein	-
AXG89_RS28030	265600..265899	+	300	WP_062173691.1	H-NS histone family protein	-
AXG89_RS28035	266193..266903	-	711	WP_062173689.1	translesion DNA synthesis-associated protein ImuA	-
AXG89_RS28040	267187..267585	+	399	WP_062173687.1	response regulator	-
AXG89_RS28045	267866..268114	-	249	WP_062173685.1	hypothetical protein	-
AXG89_RS42430	268117..268308	-	192	Protein_248	DUF3717 domain-containing protein	-
AXG89_RS28055	268819..269115	+	297	WP_062173683.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AXG89_RS28060	269118..269519	+	402	WP_062173681.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AXG89_RS28065	269547..270038	-	492	WP_062173679.1	hypothetical protein	-
AXG89_RS28070	270797..271696	+	900	WP_062174116.1	DMT family transporter	-
AXG89_RS28085	273080..274498	-	1419	WP_062173676.1	inorganic phosphate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katA	1..793876	793876

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (3-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11096.79 Da
• Isoelectric Point: 6.4590

>T60652 WP_062173683.1 NZ_CP014309:268819-269115 [Burkholderia sp. PAMC 26561]
MDKNTPHCKLSIVKQLVEADQVRTTRSAREGAAALGFDFDEMRAVVIALTTKDFFKSMTTYDDHKVWQDVYRPVTSAGPV
YLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T60652 NZ_CP014309:268819-269115 [Burkholderia sp. PAMC 26561]
ATGGACAAGAATACGCCCCATTGCAAGCTATCCATCGTCAAACAACTCGTAGAGGCGGATCAGGTTCGTACCACGCGGTC
GGCGCGTGAAGGCGCAGCAGCATTAGGTTTTGATTTTGATGAAATGCGGGCCGTGGTTATCGCACTGACGACCAAAGATT
TTTTTAAGAGCATGACAACATATGATGATCACAAGGTATGGCAGGACGTGTATCGGCCCGTGACGAGCGCCGGGCCGGTG
TACCTCAAGTTGACCGTCATCGACGATGTGCTGATCGTATCGTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14695.99 Da
• Isoelectric Point: 7.6984

>AT60652 WP_062173681.1 NZ_CP014309:269118-269519 [Burkholderia sp. PAMC 26561]
MKCPSCGAAKLVHETRDLPYVYKGQTLSLEQVTGDFCPACDEAVLDAAESRRTMALMKEFNVKVNSELADPAFILSVRKK
LNLDQREAGEIFGGGTNAFSRYETGKTKPPVALVKLLKVLYHHPELLQEVRAA

Nucleotide

• Length: 402 bp

>AT60652 NZ_CP014309:269118-269519 [Burkholderia sp. PAMC 26561]
ATGAAATGCCCGTCTTGTGGTGCGGCTAAGCTGGTGCATGAGACTCGCGACCTACCGTATGTGTACAAGGGTCAAACGTT
ATCCCTTGAGCAGGTGACCGGTGACTTTTGTCCGGCGTGCGACGAGGCAGTTCTCGACGCTGCGGAGTCGCGGCGCACGA
TGGCGCTGATGAAGGAATTCAACGTGAAGGTGAATTCTGAGCTTGCCGATCCTGCGTTTATCTTGAGCGTGCGAAAGAAG
CTGAATCTTGACCAGCGCGAAGCAGGAGAGATTTTCGGCGGTGGCACGAATGCATTTTCTCGCTATGAAACCGGGAAAAC
AAAACCACCCGTTGCATTGGTGAAGCTGTTGAAGGTGCTGTATCACCACCCCGAATTATTGCAAGAGGTAAGGGCCGCAT
AG