Detailed information of TA system TA060649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 565605..566305
• Replicon: plasmid unnamed1
• Accession: NZ_CP014308
• Organism: Burkholderia sp. PAMC 26561

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: AXG89_RS25480
• Protein ID: WP_062173683.1
• Coordinates: 566009..566305 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: AXG89_RS25475
• Protein ID: WP_062173681.1
• Coordinates: 565605..566006 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXG89_RS25450	560626..562044	+	1419	WP_062173676.1	inorganic phosphate transporter	-
AXG89_RS25465	563428..564327	-	900	WP_062174116.1	DMT family transporter	-
AXG89_RS25470	565086..565577	+	492	WP_062173679.1	hypothetical protein	-
AXG89_RS25475	565605..566006	-	402	WP_062173681.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AXG89_RS25480	566009..566305	-	297	WP_062173683.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AXG89_RS42340	566816..567007	+	192	Protein_490	DUF3717 domain-containing protein	-
AXG89_RS25490	567010..567258	+	249	WP_062173685.1	hypothetical protein	-
AXG89_RS25495	567539..567937	-	399	WP_062173687.1	response regulator	-
AXG89_RS25500	568221..568931	+	711	WP_062173689.1	translesion DNA synthesis-associated protein ImuA	-
AXG89_RS25505	569225..569524	-	300	WP_062173691.1	H-NS histone family protein	-
AXG89_RS25510	570235..571190	-	956	Protein_495	SOS response-associated peptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	katA	1..793818	793818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (3-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (78-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11096.79 Da
• Isoelectric Point: 6.4590

>T60649 WP_062173683.1 NZ_CP014308:c566305-566009 [Burkholderia sp. PAMC 26561]
MDKNTPHCKLSIVKQLVEADQVRTTRSAREGAAALGFDFDEMRAVVIALTTKDFFKSMTTYDDHKVWQDVYRPVTSAGPV
YLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T60649 NZ_CP014308:c566305-566009 [Burkholderia sp. PAMC 26561]
ATGGACAAGAATACGCCCCATTGCAAGCTATCCATCGTCAAACAACTCGTAGAGGCGGATCAGGTTCGTACCACGCGGTC
GGCGCGTGAAGGCGCAGCAGCATTAGGTTTTGATTTTGATGAAATGCGGGCCGTGGTTATCGCACTGACGACCAAAGATT
TTTTTAAGAGCATGACAACATATGATGATCACAAGGTATGGCAGGACGTGTATCGGCCCGTGACGAGCGCCGGGCCGGTG
TACCTCAAGTTGACCGTCATCGACGATGTGCTGATCGTATCGTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14695.99 Da
• Isoelectric Point: 7.6984

>AT60649 WP_062173681.1 NZ_CP014308:c566006-565605 [Burkholderia sp. PAMC 26561]
MKCPSCGAAKLVHETRDLPYVYKGQTLSLEQVTGDFCPACDEAVLDAAESRRTMALMKEFNVKVNSELADPAFILSVRKK
LNLDQREAGEIFGGGTNAFSRYETGKTKPPVALVKLLKVLYHHPELLQEVRAA

Nucleotide

• Length: 402 bp

>AT60649 NZ_CP014308:c566006-565605 [Burkholderia sp. PAMC 26561]
ATGAAATGCCCGTCTTGTGGTGCGGCTAAGCTGGTGCATGAGACTCGCGACCTACCGTATGTGTACAAGGGTCAAACGTT
ATCCCTTGAGCAGGTGACCGGTGACTTTTGTCCGGCGTGCGACGAGGCAGTTCTCGACGCTGCGGAGTCGCGGCGCACGA
TGGCGCTGATGAAGGAATTCAACGTGAAGGTGAATTCTGAGCTTGCCGATCCTGCGTTTATCTTGAGCGTGCGAAAGAAG
CTGAATCTTGACCAGCGCGAAGCAGGAGAGATTTTCGGCGGTGGCACGAATGCATTTTCTCGCTATGAAACCGGGAAAAC
AAAACCACCCGTTGCATTGGTGAAGCTGTTGAAGGTGCTGTATCACCACCCCGAATTATTGCAAGAGGTAAGGGCCGCAT
AG