Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1375071..1375293 Replicon chromosome
Accession NZ_CP014272
Organism Escherichia coli K-12 strain K-12 C3026

Toxin (Protein)


Gene name ldrD Uniprot ID J7R083
Locus tag C3026_RS07115 Protein ID WP_000170963.1
Coordinates 1375071..1375178 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1375226..1375293 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3026_RS07085 1370380..1371462 + 1083 WP_000804726.1 peptide chain release factor 1 -
C3026_RS07090 1371462..1372295 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
C3026_RS07095 1372292..1372684 + 393 WP_000200374.1 invasion regulator SirB2 -
C3026_RS07100 1372688..1373497 + 810 WP_001257044.1 invasion regulator SirB1 -
C3026_RS07105 1373533..1374387 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
C3026_RS07110 1374536..1374643 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 1374691..1374757 + 67 NuclAT_34 - -
- 1374691..1374757 + 67 NuclAT_34 - -
- 1374691..1374757 + 67 NuclAT_34 - -
- 1374691..1374757 + 67 NuclAT_34 - -
- 1374691..1374757 + 67 NuclAT_36 - -
- 1374691..1374757 + 67 NuclAT_36 - -
- 1374691..1374757 + 67 NuclAT_36 - -
- 1374691..1374757 + 67 NuclAT_36 - -
- 1374691..1374757 + 67 NuclAT_38 - -
- 1374691..1374757 + 67 NuclAT_38 - -
- 1374691..1374757 + 67 NuclAT_38 - -
- 1374691..1374757 + 67 NuclAT_38 - -
- 1374691..1374757 + 67 NuclAT_40 - -
- 1374691..1374757 + 67 NuclAT_40 - -
- 1374691..1374757 + 67 NuclAT_40 - -
- 1374691..1374757 + 67 NuclAT_40 - -
- 1374691..1374757 + 67 NuclAT_42 - -
- 1374691..1374757 + 67 NuclAT_42 - -
- 1374691..1374757 + 67 NuclAT_42 - -
- 1374691..1374757 + 67 NuclAT_42 - -
- 1374691..1374757 + 67 NuclAT_44 - -
- 1374691..1374757 + 67 NuclAT_44 - -
- 1374691..1374757 + 67 NuclAT_44 - -
- 1374691..1374757 + 67 NuclAT_44 - -
- 1374693..1374758 + 66 NuclAT_18 - -
- 1374693..1374758 + 66 NuclAT_18 - -
- 1374693..1374758 + 66 NuclAT_18 - -
- 1374693..1374758 + 66 NuclAT_18 - -
- 1374693..1374758 + 66 NuclAT_21 - -
- 1374693..1374758 + 66 NuclAT_21 - -
- 1374693..1374758 + 66 NuclAT_21 - -
- 1374693..1374758 + 66 NuclAT_21 - -
- 1374693..1374758 + 66 NuclAT_24 - -
- 1374693..1374758 + 66 NuclAT_24 - -
- 1374693..1374758 + 66 NuclAT_24 - -
- 1374693..1374758 + 66 NuclAT_24 - -
- 1374693..1374758 + 66 NuclAT_27 - -
- 1374693..1374758 + 66 NuclAT_27 - -
- 1374693..1374758 + 66 NuclAT_27 - -
- 1374693..1374758 + 66 NuclAT_27 - -
- 1374693..1374758 + 66 NuclAT_30 - -
- 1374693..1374758 + 66 NuclAT_30 - -
- 1374693..1374758 + 66 NuclAT_30 - -
- 1374693..1374758 + 66 NuclAT_30 - -
- 1374693..1374758 + 66 NuclAT_33 - -
- 1374693..1374758 + 66 NuclAT_33 - -
- 1374693..1374758 + 66 NuclAT_33 - -
- 1374693..1374758 + 66 NuclAT_33 - -
C3026_RS07115 1375071..1375178 - 108 WP_000170963.1 small toxic polypeptide LdrB Toxin
- 1375226..1375293 + 68 NuclAT_17 - Antitoxin
- 1375226..1375293 + 68 NuclAT_17 - Antitoxin
- 1375226..1375293 + 68 NuclAT_17 - Antitoxin
- 1375226..1375293 + 68 NuclAT_17 - Antitoxin
- 1375226..1375293 + 68 NuclAT_20 - Antitoxin
- 1375226..1375293 + 68 NuclAT_20 - Antitoxin
- 1375226..1375293 + 68 NuclAT_20 - Antitoxin
- 1375226..1375293 + 68 NuclAT_20 - Antitoxin
- 1375226..1375293 + 68 NuclAT_23 - Antitoxin
- 1375226..1375293 + 68 NuclAT_23 - Antitoxin
- 1375226..1375293 + 68 NuclAT_23 - Antitoxin
- 1375226..1375293 + 68 NuclAT_23 - Antitoxin
- 1375226..1375293 + 68 NuclAT_26 - Antitoxin
- 1375226..1375293 + 68 NuclAT_26 - Antitoxin
- 1375226..1375293 + 68 NuclAT_26 - Antitoxin
- 1375226..1375293 + 68 NuclAT_26 - Antitoxin
- 1375226..1375293 + 68 NuclAT_29 - Antitoxin
- 1375226..1375293 + 68 NuclAT_29 - Antitoxin
- 1375226..1375293 + 68 NuclAT_29 - Antitoxin
- 1375226..1375293 + 68 NuclAT_29 - Antitoxin
- 1375226..1375293 + 68 NuclAT_32 - Antitoxin
- 1375226..1375293 + 68 NuclAT_32 - Antitoxin
- 1375226..1375293 + 68 NuclAT_32 - Antitoxin
- 1375226..1375293 + 68 NuclAT_32 - Antitoxin
- 1375227..1375292 + 66 NuclAT_35 - -
- 1375227..1375292 + 66 NuclAT_35 - -
- 1375227..1375292 + 66 NuclAT_35 - -
- 1375227..1375292 + 66 NuclAT_35 - -
- 1375227..1375292 + 66 NuclAT_37 - -
- 1375227..1375292 + 66 NuclAT_37 - -
- 1375227..1375292 + 66 NuclAT_37 - -
- 1375227..1375292 + 66 NuclAT_37 - -
- 1375227..1375292 + 66 NuclAT_39 - -
- 1375227..1375292 + 66 NuclAT_39 - -
- 1375227..1375292 + 66 NuclAT_39 - -
- 1375227..1375292 + 66 NuclAT_39 - -
- 1375227..1375292 + 66 NuclAT_41 - -
- 1375227..1375292 + 66 NuclAT_41 - -
- 1375227..1375292 + 66 NuclAT_41 - -
- 1375227..1375292 + 66 NuclAT_41 - -
- 1375227..1375292 + 66 NuclAT_43 - -
- 1375227..1375292 + 66 NuclAT_43 - -
- 1375227..1375292 + 66 NuclAT_43 - -
- 1375227..1375292 + 66 NuclAT_43 - -
- 1375227..1375292 + 66 NuclAT_45 - -
- 1375227..1375292 + 66 NuclAT_45 - -
- 1375227..1375292 + 66 NuclAT_45 - -
- 1375227..1375292 + 66 NuclAT_45 - -
C3026_RS07120 1375606..1375713 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
- 1375761..1375828 + 68 NuclAT_16 - -
- 1375761..1375828 + 68 NuclAT_16 - -
- 1375761..1375828 + 68 NuclAT_16 - -
- 1375761..1375828 + 68 NuclAT_16 - -
- 1375761..1375828 + 68 NuclAT_19 - -
- 1375761..1375828 + 68 NuclAT_19 - -
- 1375761..1375828 + 68 NuclAT_19 - -
- 1375761..1375828 + 68 NuclAT_19 - -
- 1375761..1375828 + 68 NuclAT_22 - -
- 1375761..1375828 + 68 NuclAT_22 - -
- 1375761..1375828 + 68 NuclAT_22 - -
- 1375761..1375828 + 68 NuclAT_22 - -
- 1375761..1375828 + 68 NuclAT_25 - -
- 1375761..1375828 + 68 NuclAT_25 - -
- 1375761..1375828 + 68 NuclAT_25 - -
- 1375761..1375828 + 68 NuclAT_25 - -
- 1375761..1375828 + 68 NuclAT_28 - -
- 1375761..1375828 + 68 NuclAT_28 - -
- 1375761..1375828 + 68 NuclAT_28 - -
- 1375761..1375828 + 68 NuclAT_28 - -
- 1375761..1375828 + 68 NuclAT_31 - -
- 1375761..1375828 + 68 NuclAT_31 - -
- 1375761..1375828 + 68 NuclAT_31 - -
- 1375761..1375828 + 68 NuclAT_31 - -
C3026_RS07125 1376117..1377217 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
C3026_RS07130 1377487..1377717 + 231 WP_001146444.1 putative cation transport regulator ChaB -
C3026_RS07135 1377875..1378570 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
C3026_RS07140 1378614..1378967 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3971.74 Da        Isoelectric Point: 11.4779

>T60567 WP_000170963.1 NZ_CP014272:c1375178-1375071 [Escherichia coli K-12]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T60567 NZ_CP014272:c1375178-1375071 [Escherichia coli K-12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT60567 NZ_CP014272:1375226-1375293 [Escherichia coli K-12]
GTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References