Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3831982..3832675 Replicon chromosome
Accession NZ_CP014269
Organism Escherichia coli B strain C3029

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag C3029_RS19105 Protein ID WP_000415584.1
Coordinates 3832379..3832675 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag C3029_RS19100 Protein ID WP_000650107.1
Coordinates 3831982..3832377 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3029_RS19090 3827846..3830104 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
C3029_RS19095 3830242..3831849 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
C3029_RS19100 3831982..3832377 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
C3029_RS19105 3832379..3832675 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
C3029_RS19110 3832880..3833362 - 483 WP_000183505.1 transcriptional regulator -
C3029_RS19115 3833415..3833807 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
C3029_RS19120 3833959..3834618 + 660 WP_001221493.1 two-component system response regulator QseB -
C3029_RS19125 3834615..3835964 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
C3029_RS19130 3836010..3836342 - 333 WP_000917684.1 DUF2645 family protein -
C3029_RS19135 3836661..3837242 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
C3029_RS19140 3837273..3837587 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T60509 WP_000415584.1 NZ_CP014269:c3832675-3832379 [Escherichia coli B]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T60509 NZ_CP014269:c3832675-3832379 [Escherichia coli B]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT60509 WP_000650107.1 NZ_CP014269:c3832377-3831982 [Escherichia coli B]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT60509 NZ_CP014269:c3832377-3831982 [Escherichia coli B]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References