Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2072416..2072636 Replicon chromosome
Accession NZ_CP014269
Organism Escherichia coli B strain C3029

Toxin (Protein)


Gene name ldrD Uniprot ID E3PKK3
Locus tag C3029_RS10470 Protein ID WP_000170951.1
Coordinates 2072416..2072523 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2072573..2072636 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3029_RS10445 2068262..2069344 + 1083 WP_000804726.1 peptide chain release factor 1 -
C3029_RS10450 2069344..2070177 + 834 WP_000456454.1 peptide chain release factor N(5)-glutamine methyltransferase -
C3029_RS10455 2070174..2070566 + 393 WP_000200373.1 invasion regulator SirB2 -
C3029_RS10460 2070570..2071379 + 810 WP_001257044.1 invasion regulator SirB1 -
C3029_RS10465 2071415..2072269 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
C3029_RS10470 2072416..2072523 - 108 WP_000170951.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2072573..2072636 + 64 NuclAT_32 - Antitoxin
- 2072573..2072636 + 64 NuclAT_32 - Antitoxin
- 2072573..2072636 + 64 NuclAT_32 - Antitoxin
- 2072573..2072636 + 64 NuclAT_32 - Antitoxin
- 2072573..2072636 + 64 NuclAT_35 - Antitoxin
- 2072573..2072636 + 64 NuclAT_35 - Antitoxin
- 2072573..2072636 + 64 NuclAT_35 - Antitoxin
- 2072573..2072636 + 64 NuclAT_35 - Antitoxin
- 2072573..2072636 + 64 NuclAT_38 - Antitoxin
- 2072573..2072636 + 64 NuclAT_38 - Antitoxin
- 2072573..2072636 + 64 NuclAT_38 - Antitoxin
- 2072573..2072636 + 64 NuclAT_38 - Antitoxin
- 2072573..2072636 + 64 NuclAT_41 - Antitoxin
- 2072573..2072636 + 64 NuclAT_41 - Antitoxin
- 2072573..2072636 + 64 NuclAT_41 - Antitoxin
- 2072573..2072636 + 64 NuclAT_41 - Antitoxin
- 2072573..2072636 + 64 NuclAT_47 - Antitoxin
- 2072573..2072636 + 64 NuclAT_47 - Antitoxin
- 2072573..2072636 + 64 NuclAT_47 - Antitoxin
- 2072573..2072636 + 64 NuclAT_47 - Antitoxin
- 2072573..2072636 + 64 NuclAT_50 - Antitoxin
- 2072573..2072636 + 64 NuclAT_50 - Antitoxin
- 2072573..2072636 + 64 NuclAT_50 - Antitoxin
- 2072573..2072636 + 64 NuclAT_50 - Antitoxin
C3029_RS10475 2072951..2073058 - 108 WP_000170963.1 small toxic polypeptide LdrB -
- 2073106..2073171 + 66 NuclAT_30 - -
- 2073106..2073171 + 66 NuclAT_30 - -
- 2073106..2073171 + 66 NuclAT_30 - -
- 2073106..2073171 + 66 NuclAT_30 - -
- 2073106..2073171 + 66 NuclAT_33 - -
- 2073106..2073171 + 66 NuclAT_33 - -
- 2073106..2073171 + 66 NuclAT_33 - -
- 2073106..2073171 + 66 NuclAT_33 - -
- 2073106..2073171 + 66 NuclAT_36 - -
- 2073106..2073171 + 66 NuclAT_36 - -
- 2073106..2073171 + 66 NuclAT_36 - -
- 2073106..2073171 + 66 NuclAT_36 - -
- 2073106..2073171 + 66 NuclAT_39 - -
- 2073106..2073171 + 66 NuclAT_39 - -
- 2073106..2073171 + 66 NuclAT_39 - -
- 2073106..2073171 + 66 NuclAT_39 - -
- 2073106..2073171 + 66 NuclAT_45 - -
- 2073106..2073171 + 66 NuclAT_45 - -
- 2073106..2073171 + 66 NuclAT_45 - -
- 2073106..2073171 + 66 NuclAT_45 - -
- 2073106..2073171 + 66 NuclAT_48 - -
- 2073106..2073171 + 66 NuclAT_48 - -
- 2073106..2073171 + 66 NuclAT_48 - -
- 2073106..2073171 + 66 NuclAT_48 - -
- 2073106..2073173 + 68 NuclAT_16 - -
- 2073106..2073173 + 68 NuclAT_16 - -
- 2073106..2073173 + 68 NuclAT_16 - -
- 2073106..2073173 + 68 NuclAT_16 - -
- 2073106..2073173 + 68 NuclAT_18 - -
- 2073106..2073173 + 68 NuclAT_18 - -
- 2073106..2073173 + 68 NuclAT_18 - -
- 2073106..2073173 + 68 NuclAT_18 - -
- 2073106..2073173 + 68 NuclAT_20 - -
- 2073106..2073173 + 68 NuclAT_20 - -
- 2073106..2073173 + 68 NuclAT_20 - -
- 2073106..2073173 + 68 NuclAT_20 - -
- 2073106..2073173 + 68 NuclAT_22 - -
- 2073106..2073173 + 68 NuclAT_22 - -
- 2073106..2073173 + 68 NuclAT_22 - -
- 2073106..2073173 + 68 NuclAT_22 - -
- 2073106..2073173 + 68 NuclAT_24 - -
- 2073106..2073173 + 68 NuclAT_24 - -
- 2073106..2073173 + 68 NuclAT_24 - -
- 2073106..2073173 + 68 NuclAT_24 - -
- 2073106..2073173 + 68 NuclAT_26 - -
- 2073106..2073173 + 68 NuclAT_26 - -
- 2073106..2073173 + 68 NuclAT_26 - -
- 2073106..2073173 + 68 NuclAT_26 - -
C3029_RS10480 2073486..2073593 - 108 WP_000170965.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2073641..2073706 + 66 NuclAT_31 - -
- 2073641..2073706 + 66 NuclAT_31 - -
- 2073641..2073706 + 66 NuclAT_31 - -
- 2073641..2073706 + 66 NuclAT_31 - -
- 2073641..2073706 + 66 NuclAT_34 - -
- 2073641..2073706 + 66 NuclAT_34 - -
- 2073641..2073706 + 66 NuclAT_34 - -
- 2073641..2073706 + 66 NuclAT_34 - -
- 2073641..2073706 + 66 NuclAT_37 - -
- 2073641..2073706 + 66 NuclAT_37 - -
- 2073641..2073706 + 66 NuclAT_37 - -
- 2073641..2073706 + 66 NuclAT_37 - -
- 2073641..2073706 + 66 NuclAT_40 - -
- 2073641..2073706 + 66 NuclAT_40 - -
- 2073641..2073706 + 66 NuclAT_40 - -
- 2073641..2073706 + 66 NuclAT_40 - -
- 2073641..2073706 + 66 NuclAT_46 - -
- 2073641..2073706 + 66 NuclAT_46 - -
- 2073641..2073706 + 66 NuclAT_46 - -
- 2073641..2073706 + 66 NuclAT_46 - -
- 2073641..2073706 + 66 NuclAT_49 - -
- 2073641..2073706 + 66 NuclAT_49 - -
- 2073641..2073706 + 66 NuclAT_49 - -
- 2073641..2073706 + 66 NuclAT_49 - -
- 2073641..2073708 + 68 NuclAT_15 - -
- 2073641..2073708 + 68 NuclAT_15 - -
- 2073641..2073708 + 68 NuclAT_15 - -
- 2073641..2073708 + 68 NuclAT_15 - -
- 2073641..2073708 + 68 NuclAT_17 - -
- 2073641..2073708 + 68 NuclAT_17 - -
- 2073641..2073708 + 68 NuclAT_17 - -
- 2073641..2073708 + 68 NuclAT_17 - -
- 2073641..2073708 + 68 NuclAT_19 - -
- 2073641..2073708 + 68 NuclAT_19 - -
- 2073641..2073708 + 68 NuclAT_19 - -
- 2073641..2073708 + 68 NuclAT_19 - -
- 2073641..2073708 + 68 NuclAT_21 - -
- 2073641..2073708 + 68 NuclAT_21 - -
- 2073641..2073708 + 68 NuclAT_21 - -
- 2073641..2073708 + 68 NuclAT_21 - -
- 2073641..2073708 + 68 NuclAT_23 - -
- 2073641..2073708 + 68 NuclAT_23 - -
- 2073641..2073708 + 68 NuclAT_23 - -
- 2073641..2073708 + 68 NuclAT_23 - -
- 2073641..2073708 + 68 NuclAT_25 - -
- 2073641..2073708 + 68 NuclAT_25 - -
- 2073641..2073708 + 68 NuclAT_25 - -
- 2073641..2073708 + 68 NuclAT_25 - -
C3029_RS10485 2073998..2075098 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
C3029_RS10490 2075368..2075598 + 231 WP_001146444.1 putative cation transport regulator ChaB -
C3029_RS10495 2075756..2076451 + 696 WP_012775986.1 glutathione-specific gamma-glutamylcyclotransferase -
C3029_RS10500 2076495..2076848 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3961.74 Da        Isoelectric Point: 9.1413

>T60491 WP_000170951.1 NZ_CP014269:c2072523-2072416 [Escherichia coli B]
MTLAQFAMIFWDDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T60491 NZ_CP014269:c2072523-2072416 [Escherichia coli B]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 64 bp

>AT60491 NZ_CP014269:2072573-2072636 [Escherichia coli B]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGATTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PKK3

Antitoxin

Download structure file

References