60483

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3741721..3742414 Replicon chromosome
Accession NZ_CP014268
Organism Escherichia coli B strain C2566

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag C2566_RS18475 Protein ID WP_000415584.1
Coordinates 3742118..3742414 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag C2566_RS18470 Protein ID WP_000650107.1
Coordinates 3741721..3742116 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2566_RS18460 3737585..3739843 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
C2566_RS18465 3739981..3741588 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
C2566_RS18470 3741721..3742116 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
C2566_RS18475 3742118..3742414 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
C2566_RS18480 3742619..3743101 - 483 WP_000183505.1 transcriptional regulator -
C2566_RS18485 3743154..3743546 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
C2566_RS18490 3743698..3744357 + 660 WP_001221493.1 two-component system response regulator QseB -
C2566_RS18495 3744354..3745703 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
C2566_RS18500 3745749..3746081 - 333 WP_000917684.1 DUF2645 family protein -
C2566_RS18505 3746400..3746981 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
C2566_RS18510 3747012..3747326 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T60483 WP_000415584.1 NZ_CP014268:c3742414-3742118 [Escherichia coli B]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T60483 NZ_CP014268:c3742414-3742118 [Escherichia coli B]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT60483 WP_000650107.1 NZ_CP014268:c3742116-3741721 [Escherichia coli B]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT60483 NZ_CP014268:c3742116-3741721 [Escherichia coli B]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References