Detailed information of TA system TA060458

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1739191..1739703
• Replicon: chromosome
• Accession: NZ_CP014264
• Organism: Streptococcus sp. oral taxon 431 strain F0610 (5-114)

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: G0I700
• Locus tag: AXE83_RS08130
• Protein ID: WP_000924730.1
• Coordinates: 1739191..1739445 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: AXE83_RS08135
• Protein ID: WP_190279310.1
• Coordinates: 1739449..1739703 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXE83_RS08115	1736259..1736573	-	315	WP_006146546.1	DNA-directed RNA polymerase subunit omega	-
AXE83_RS08120	1736598..1737224	-	627	WP_060956086.1	guanylate kinase	-
AXE83_RS08125	1737361..1738974	-	1614	WP_060956087.1	ribonuclease Y	-
AXE83_RS08130	1739191..1739445	-	255	WP_000924730.1	Txe/YoeB family addiction module toxin	Toxin
AXE83_RS08135	1739449..1739703	-	255	WP_190279310.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AXE83_RS08140	1739835..1740932	-	1098	WP_060956089.1	nucleotidyltransferase	-
AXE83_RS08145	1740942..1741688	-	747	WP_080979398.1	class I SAM-dependent methyltransferase	-
AXE83_RS08150	1741793..1742146	-	354	WP_049503418.1	ribosome silencing factor	-
AXE83_RS08155	1742159..1742659	-	501	WP_060956090.1	cysteine hydrolase	-
AXE83_RS08160	1742660..1743253	-	594	WP_060956091.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
AXE83_RS08165	1743253..1743882	-	630	WP_060956092.1	nicotinate-nucleotide adenylyltransferase	-
AXE83_RS08170	1743934..1744245	-	312	WP_000060171.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10102.55 Da
• Isoelectric Point: 7.9716

>T60458 WP_000924730.1 NZ_CP014264:c1739445-1739191 [Streptococcus sp. oral taxon 431]
MLLKFTEDAWADYCYWQTQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T60458 NZ_CP014264:c1739445-1739191 [Streptococcus sp. oral taxon 431]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCGGATTATTGCTACTGGCAAACTCAGGACAAGAAAACATTAAAAAGAAT
CAACAAACTAATCAAGGATATTCAACGCGATCCATTTACAGGAATTGGTAAACCAGAACCACTCAAGTATGACTATCAAG
GAGCTTGGTCACGGCGTATTGACGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCTTTC
AAAGATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9832.17 Da
• Isoelectric Point: 5.1312

>AT60458 WP_190279310.1 NZ_CP014264:c1739703-1739449 [Streptococcus sp. oral taxon 431]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMSQVRVGHTQVH
MIEE

Nucleotide

• Length: 255 bp

>AT60458 NZ_CP014264:c1739703-1739449 [Streptococcus sp. oral taxon 431]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTGAAGGATTATATGAAGAAGGTAAACGATGAATTTGAACCTTT
GACAGTTGTCAACAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAAGAAACTTTGA
GAATTGCTCAGAATAAGGAGCTTTCTGACAAGGTCTTGCGAGGAATGTCCCAAGTTCGTGTGGGACACACTCAGGTGCAT
ATGATTGAGGAGTGA

Structures

Toxin

• AlphaFold DB: G0I700