60455

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3831719..3832308 Replicon chromosome
Accession NZ_CP014263
Organism Spirosoma montaniterrae strain DY10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AWR27_RS16555 Protein ID WP_077132192.1
Coordinates 3832048..3832308 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AWR27_RS16550 Protein ID WP_077132191.1
Coordinates 3831719..3832033 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWR27_RS16525 3826741..3827715 - 975 WP_077132186.1 6-phosphofructokinase -
AWR27_RS16530 3827847..3828593 - 747 WP_077132187.1 glycosyltransferase -
AWR27_RS16535 3828652..3829956 - 1305 WP_077132188.1 glycosyltransferase family 4 protein -
AWR27_RS16540 3829953..3830759 - 807 WP_077132189.1 FkbM family methyltransferase -
AWR27_RS16545 3830811..3831653 - 843 WP_077132190.1 DUF2911 domain-containing protein -
AWR27_RS16550 3831719..3832033 - 315 WP_077132191.1 HigA family addiction module antidote protein Antitoxin
AWR27_RS16555 3832048..3832308 - 261 WP_077132192.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AWR27_RS16560 3832501..3835944 + 3444 WP_077132193.1 pyruvate carboxylase -
AWR27_RS16565 3835978..3836697 - 720 WP_077132194.1 sterol desaturase family protein -
AWR27_RS16570 3836885..3837286 + 402 WP_077132195.1 DUF4870 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9773.14 Da        Isoelectric Point: 6.6354

>T60455 WP_077132192.1 NZ_CP014263:c3832308-3832048 [Spirosoma montaniterrae]
MICSIHHKGLRLYYEEGNGAKLPPAYLKKIARLLTSLDAVSSVDDIVQLGSGDMTDYWAIHVSANYKLIFRFDKGDVHDV
NYVDYH

Download         Length: 261 bp

>T60455 NZ_CP014263:c3832308-3832048 [Spirosoma montaniterrae]
ATGATTTGCTCGATACACCATAAAGGTTTACGACTTTACTATGAAGAAGGTAATGGAGCAAAATTGCCCCCAGCTTATTT
GAAAAAAATTGCCCGTTTGCTGACATCGTTGGATGCCGTTTCATCGGTTGACGATATAGTGCAACTGGGTTCCGGCGATA
TGACCGATTACTGGGCTATTCATGTCAGTGCCAACTATAAACTTATTTTTCGCTTTGATAAGGGTGATGTACACGACGTT
AACTATGTAGATTACCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11830.60 Da        Isoelectric Point: 9.9205

>AT60455 WP_077132191.1 NZ_CP014263:c3832033-3831719 [Spirosoma montaniterrae]
MLKRNLPPSHPGEILREDFIKERGLTITEVAKGLNMARANLSVIVNEHAGISPELAVKLAIAFGNTPQFWINLQKNYELW
HAERTVDRDSIRRFVSEPLNRQAA

Download         Length: 315 bp

>AT60455 NZ_CP014263:c3832033-3831719 [Spirosoma montaniterrae]
ATGTTGAAACGAAATTTGCCACCGAGCCATCCTGGCGAAATCTTACGGGAAGACTTTATTAAAGAACGCGGCCTGACCAT
TACCGAAGTAGCAAAAGGCTTAAATATGGCGCGGGCAAATTTGTCGGTTATTGTGAATGAACATGCGGGTATTAGCCCGG
AATTAGCCGTAAAACTCGCTATAGCTTTCGGGAACACGCCCCAATTCTGGATTAATTTGCAGAAGAATTACGAATTGTGG
CACGCAGAGCGGACGGTTGACCGGGACTCTATTCGTCGGTTCGTAAGTGAGCCACTTAACAGGCAAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References