60449

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2656943..2658183 Replicon chromosome
Accession NZ_CP014255
Organism Legionella pneumophila subsp. pascullei strain F-4185

Toxin (Protein)


Gene name HipT Uniprot ID A0A140J6I8
Locus tag AXF35_RS12020 Protein ID WP_027222482.1
Coordinates 2657248..2658183 (+) Length 312 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A140J6I7
Locus tag AXF35_RS12015 Protein ID WP_027222481.1
Coordinates 2656943..2657251 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF35_RS11980 2652415..2653275 + 861 WP_011947276.1 DUF2608 domain-containing protein -
AXF35_RS11985 2653625..2653924 - 300 WP_027222477.1 hypothetical protein -
AXF35_RS11990 2653935..2654246 - 312 WP_011947278.1 cupin -
AXF35_RS11995 2654237..2654518 - 282 WP_050598290.1 hypothetical protein -
AXF35_RS12000 2654694..2655167 + 474 WP_027222478.1 hypothetical protein -
AXF35_RS12005 2655357..2656274 + 918 WP_027222479.1 LysR family transcriptional regulator -
AXF35_RS12010 2656719..2656946 + 228 WP_027222480.1 helix-turn-helix transcriptional regulator -
AXF35_RS12015 2656943..2657251 + 309 WP_027222481.1 HipA N-terminal domain-containing protein Antitoxin
AXF35_RS12020 2657248..2658183 + 936 WP_027222482.1 HipA domain-containing protein Toxin
AXF35_RS12030 2658485..2659630 + 1146 WP_027222483.1 hypothetical protein -
AXF35_RS12035 2659640..2660827 - 1188 WP_061773169.1 fatty acid desaturase -
AXF35_RS12040 2660952..2661119 - 168 WP_011214444.1 DUF3309 domain-containing protein -
AXF35_RS15405 2661231..2661404 + 174 WP_158272786.1 hypothetical protein -
AXF35_RS12045 2661576..2661932 + 357 WP_027222484.1 hypothetical protein -
AXF35_RS12050 2661973..2662905 - 933 WP_027222485.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-275)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 312 a.a.        Molecular weight: 36037.79 Da        Isoelectric Point: 9.3028

>T60449 WP_027222482.1 NZ_CP014255:2657248-2658183 [Legionella pneumophila subsp. pascullei]
MKRCPITYERISDQENYSQRGLYLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSANLKIKEGCFEIVDQNG
HYILKPQSDVYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIEVVEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLKYFAVEKLGLNQKIIDGIVQEFHQIIPEWRKLVGFSFLSQQMQEKYLQLLEQRCKQLNFF

Download         Length: 936 bp

>T60449 NZ_CP014255:2657248-2658183 [Legionella pneumophila subsp. pascullei]
ATGAAACGCTGTCCTATTACTTATGAAAGGATTAGTGACCAGGAAAACTACTCGCAACGTGGATTGTATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTAGATTTAAGTGCCGATGAGCAGCGTCAGGAAGCAATCGCTCGAGTAGGAAAGATGT
CTATTCAAGGTGTTCAAAAGAAACTAAGTGCAAATCTAAAGATTAAAGAGGGATGTTTTGAAATCGTCGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATGTTTATCCAGAATTGCCGGAAAATGAAGCCATTACTATGACCCTAGCAAAAAC
CATTGGCCTTGAAGTTCCAGTTCATGGTTTAGTTTATTCTAAAGACAACAGTTTGACCTACTTTATTAAACGGTTTGATC
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTCATTGAAGTCGTAGAACAGTTTTGTACATTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTATTTAATTTCCTGGTCGGCAATGAAGATATGCATCTAAAAAATTTTTCCCTAATTACTAAGGATAGAAAAATTTCCA
TATCACCAGCCTATGATTTACTTAACTCAACTATTGCTCAAAAAAACACAAAAGAAGAAATAGCCTTGCCTCTAAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCGTTGAAAAATTAGGATTAAATCAGAAAATCATCGA
TGGGATCGTACAAGAGTTCCATCAAATAATACCTGAATGGCGAAAGCTGGTTGGTTTCAGTTTTTTATCTCAACAGATGC
AGGAAAAATATCTCCAATTGCTAGAGCAACGATGCAAGCAATTAAATTTTTTTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11664.54 Da        Isoelectric Point: 4.7719

>AT60449 WP_027222481.1 NZ_CP014255:2656943-2657251 [Legionella pneumophila subsp. pascullei]
MRKAYVSVNGIKAGILEELQGGKYQFTYFDDYQGAPVSLTMPLKNKVYYFDVFPPFFEGLLPEGIMLEALLRKYKIDRND
YFGQLIIVGQDVVGAVTIEELR

Download         Length: 309 bp

>AT60449 NZ_CP014255:2656943-2657251 [Legionella pneumophila subsp. pascullei]
ATGAGAAAAGCATATGTATCAGTGAATGGCATTAAGGCAGGAATATTAGAAGAATTACAAGGTGGAAAATATCAATTTAC
TTACTTTGATGATTATCAGGGTGCACCTGTTTCGCTCACAATGCCGTTGAAAAATAAAGTCTATTATTTTGACGTATTCC
CTCCTTTCTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGTAAATATAAGATAGATAGAAATGAC
TATTTTGGTCAATTGATAATAGTTGGCCAAGATGTCGTAGGCGCGGTGACTATTGAGGAACTAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140J6I8

Antitoxin

Source ID Structure
AlphaFold DB A0A140J6I7

References