Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 349317..349926 Replicon chromosome
Accession NZ_CP014234
Organism Moraxella osloensis strain CCUG 350

Toxin (Protein)


Gene name higB Uniprot ID A0A0X8K854
Locus tag AXE82_RS01550 Protein ID WP_062334682.1
Coordinates 349588..349926 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A120KQQ4
Locus tag AXE82_RS01545 Protein ID WP_062330561.1
Coordinates 349317..349598 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXE82_RS01530 345870..346724 + 855 WP_062330556.1 RDD family protein -
AXE82_RS01535 346776..349007 + 2232 WP_062330558.1 FtsW/RodA/SpoVE family cell cycle protein -
AXE82_RS01540 349017..349265 + 249 WP_062330559.1 hypothetical protein -
AXE82_RS01545 349317..349598 - 282 WP_062330561.1 helix-turn-helix domain-containing protein Antitoxin
AXE82_RS01550 349588..349926 - 339 WP_062334682.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AXE82_RS01555 350150..352999 + 2850 WP_197931493.1 hypothetical protein -
AXE82_RS01560 353028..354617 + 1590 WP_062330563.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-77)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12806.57 Da        Isoelectric Point: 9.8468

>T60438 WP_062334682.1 NZ_CP014234:c349926-349588 [Moraxella osloensis]
MHFIETPLFTKQIKDLTDDDNYRDLQEDLIKNPQQGDLVQGTGGVRKTRWSSSSSTGKSGGMRIIYYYIEESGKFFMLLA
YPKSKKVTLSAAEKANLRKFTNAIKQVLHNEQ

Download         Length: 339 bp

>T60438 NZ_CP014234:c349926-349588 [Moraxella osloensis]
TTGCACTTTATTGAAACACCGCTTTTTACCAAGCAAATTAAAGATTTAACAGACGATGATAATTATCGAGATTTGCAAGA
GGATTTAATAAAAAATCCCCAGCAAGGCGACCTAGTTCAAGGTACAGGCGGTGTTCGTAAAACTCGTTGGTCGTCATCAT
CTTCTACTGGTAAAAGCGGTGGTATGCGTATCATTTACTATTATATAGAGGAGTCGGGCAAGTTTTTTATGTTATTGGCT
TACCCAAAATCAAAAAAAGTCACACTATCTGCCGCAGAAAAAGCAAATTTGCGTAAATTCACAAACGCTATCAAACAGGT
ACTACACAATGAGCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10366.84 Da        Isoelectric Point: 7.0111

>AT60438 WP_062330561.1 NZ_CP014234:c349598-349317 [Moraxella osloensis]
MSNEFYDDLSLSLSQALSIAKGEAEPSRVFSYELPDIKAIRAKTGLTQAQFADKLNISSRTLQNWEQGTRHPTGATITLM
RLLEKKPELITLA

Download         Length: 282 bp

>AT60438 NZ_CP014234:c349598-349317 [Moraxella osloensis]
ATGAGCAATGAATTTTATGATGATTTATCATTATCTCTTTCTCAAGCATTAAGCATTGCCAAAGGCGAAGCCGAGCCAAG
CCGTGTTTTTAGTTATGAGTTGCCAGATATTAAGGCAATCCGAGCTAAAACAGGACTAACACAGGCACAATTCGCCGATA
AGTTAAATATAAGTTCTCGCACGTTACAAAATTGGGAGCAAGGTACAAGACACCCTACAGGGGCAACGATTACGCTCATG
CGGCTTTTGGAAAAAAAGCCAGAACTGATTACGTTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8K854

Antitoxin

Source ID Structure
AlphaFold DB A0A120KQQ4

References