Detailed information of TA system TA060437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2160009..2160514
• Replicon: chromosome
• Accession: NZ_CP014232
• Organism: Actinomyces oris strain T14V

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: AXE84_RS08665
• Protein ID: WP_081093133.1
• Coordinates: 2160248..2160514 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1F1VSH2
• Locus tag: AXE84_RS08660
• Protein ID: WP_029316340.1
• Coordinates: 2160009..2160251 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AXE84_RS08645	2155655..2156236	-	582	WP_060957591.1	hypothetical protein	-
AXE84_RS08650	2156487..2159693	+	3207	WP_060957592.1	UPF0182 family protein	-
AXE84_RS08660	2160009..2160251	+	243	WP_029316340.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AXE84_RS08665	2160248..2160514	+	267	WP_081093133.1	Txe/YoeB family addiction module toxin	Toxin
AXE84_RS08670	2160680..2161519	+	840	WP_060957594.1	polyphosphate kinase 2	-
AXE84_RS08675	2161516..2162271	-	756	WP_060957595.1	NAD-dependent protein deacylase	-
AXE84_RS08680	2162409..2162624	-	216	WP_009407243.1	DUF3107 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.16 Da
• Isoelectric Point: 10.5624

>T60437 WP_081093133.1 NZ_CP014232:2160248-2160514 [Actinomyces oris]
VSSWRIVFSRQAQKDAKKLAAAGLKPKTEKLLNLMRENPFVKPPRYEKLVGDLSGCYSRRITIQHRLVYEVHTDERTIHV
LRMWTHYE

Nucleotide

• Length: 267 bp

>T60437 NZ_CP014232:2160248-2160514 [Actinomyces oris]
GTGAGCTCGTGGCGAATCGTGTTCTCACGTCAGGCACAGAAGGACGCGAAGAAACTCGCCGCGGCGGGACTCAAGCCTAA
AACCGAGAAGCTCCTCAACCTCATGCGGGAGAATCCCTTCGTCAAACCGCCTCGTTACGAAAAGCTGGTCGGGGATCTAT
CGGGCTGCTACTCGCGGCGTATCACTATCCAGCATCGACTCGTCTACGAGGTGCACACCGACGAGAGGACCATCCATGTC
CTGAGAATGTGGACCCACTACGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8975.97 Da
• Isoelectric Point: 4.0078

>AT60437 WP_029316340.1 NZ_CP014232:2160009-2160251 [Actinomyces oris]
VSTIPVTTARSQLYRLIDQVNEDSEPLVITGQRGNAVLVGEEDWRAIQETLYLESVPGMMDSIRNARREGIEAGSEELDW

Nucleotide

• Length: 243 bp

>AT60437 NZ_CP014232:2160009-2160251 [Actinomyces oris]
GTGTCTACGATTCCAGTGACGACCGCTCGTTCTCAGTTGTATCGGCTCATCGATCAGGTCAACGAAGACTCCGAGCCGCT
GGTCATCACCGGCCAACGCGGCAATGCCGTCTTGGTGGGGGAGGAGGACTGGAGGGCGATCCAGGAGACGCTCTACCTGG
AGTCCGTCCCGGGCATGATGGACTCGATCCGGAACGCCCGACGTGAAGGCATCGAGGCGGGCTCGGAAGAACTCGACTGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1F1VSH2