Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1958954..1959468 Replicon chromosome
Accession NZ_CP014231
Organism Leptotrichia sp. oral taxon 847 strain F0260

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8JVQ2
Locus tag AXF11_RS09240 Protein ID WP_068157457.1
Coordinates 1959211..1959468 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A109W7W4
Locus tag AXF11_RS09235 Protein ID WP_053393071.1
Coordinates 1958954..1959211 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AXF11_RS10740 1954029..1954184 + 156 WP_197416825.1 hypothetical protein -
AXF11_RS10745 1954160..1954435 + 276 WP_197416869.1 AraC family transcriptional regulator -
AXF11_RS09215 1954519..1955730 + 1212 WP_068153993.1 IS256 family transposase -
AXF11_RS09220 1956103..1956417 - 315 WP_068157450.1 helix-turn-helix transcriptional regulator -
AXF11_RS09225 1956577..1956927 - 351 WP_068157452.1 cupin domain-containing protein -
AXF11_RS09230 1957243..1958631 - 1389 WP_068157455.1 MATE family efflux transporter -
AXF11_RS09235 1958954..1959211 + 258 WP_053393071.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AXF11_RS09240 1959211..1959468 + 258 WP_068157457.1 Txe/YoeB family addiction module toxin Toxin
AXF11_RS09245 1959724..1960734 + 1011 WP_068157461.1 hypothetical protein -
AXF11_RS09250 1961013..1962248 + 1236 WP_197416826.1 SEL1-like repeat protein -
AXF11_RS09255 1962267..1962509 + 243 WP_068157472.1 hypothetical protein -
AXF11_RS09260 1962741..1963031 + 291 WP_156440409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10294.88 Da        Isoelectric Point: 9.9281

>T60431 WP_068157457.1 NZ_CP014231:1959211-1959468 [Leptotrichia sp. oral taxon 847]
MNLIWNNEAWEEYIQWQKQDKKIVKKINEIIKDIKRNGNEGIGKPEPLKHELNGYWSRRITDKHRFIYKLTETNIVVIAC
ANHYK

Download         Length: 258 bp

>T60431 NZ_CP014231:1959211-1959468 [Leptotrichia sp. oral taxon 847]
ATGAATCTGATTTGGAATAATGAGGCTTGGGAAGAATATATCCAGTGGCAAAAACAGGATAAAAAAATAGTCAAAAAAAT
AAATGAAATAATAAAAGACATCAAAAGAAACGGAAATGAAGGAATAGGGAAACCTGAGCCTTTAAAGCATGAACTGAATG
GATACTGGAGCAGAAGGATTACAGATAAGCACAGGTTTATATATAAACTAACAGAAACAAATATAGTGGTTATCGCCTGT
GCAAATCATTATAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10141.46 Da        Isoelectric Point: 4.6909

>AT60431 WP_053393071.1 NZ_CP014231:1958954-1959211 [Leptotrichia sp. oral taxon 847]
MIATNYSNVRNNLKKYCDKATDDYETVIITRKNDKNVVLMSEEEYNNLMENLYIMSNKKYYNELLKRKEEVEAGNVQIHD
IIEVE

Download         Length: 258 bp

>AT60431 NZ_CP014231:1958954-1959211 [Leptotrichia sp. oral taxon 847]
ATGATAGCTACAAATTATTCAAATGTGAGAAACAATTTAAAAAAATATTGTGATAAGGCAACTGATGATTATGAAACAGT
CATTATAACAAGAAAAAACGATAAAAATGTGGTACTGATGAGTGAAGAGGAATATAACAATTTGATGGAAAATCTTTACA
TCATGTCAAATAAGAAATATTACAATGAACTATTAAAAAGAAAAGAAGAAGTAGAGGCGGGAAATGTACAAATACATGAT
ATAATTGAGGTGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8JVQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A109W7W4

References