Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ldrD-rdlD/Ldr(toxin) |
Location | 4109162..4109384 | Replicon | chromosome |
Accession | NZ_CP014225 | ||
Organism | Escherichia coli str. K-12 substr. MG1655 strain K-12 |
Toxin (Protein)
Gene name | ldrD | Uniprot ID | D3H2K1 |
Locus tag | AW869_RS20315 | Protein ID | WP_000170955.1 |
Coordinates | 4109162..4109269 (-) | Length | 36 a.a. |
Antitoxin (RNA)
Gene name | rdlD | ||
Locus tag | - | ||
Coordinates | 4109317..4109384 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AW869_RS20285 | 4105018..4105851 | + | 834 | WP_000456467.1 | peptide chain release factor N(5)-glutamine methyltransferase | - |
AW869_RS20290 | 4105848..4106240 | + | 393 | WP_000200374.1 | invasion regulator SirB2 | - |
AW869_RS20295 | 4106244..4107053 | + | 810 | WP_001257044.1 | invasion regulator SirB1 | - |
AW869_RS20300 | 4107089..4107943 | + | 855 | WP_000811065.1 | 3-deoxy-8-phosphooctulonate synthase | - |
AW869_RS20305 | 4108092..4108199 | - | 108 | WP_000170955.1 | small toxic polypeptide LdrA/LdrC | - |
- | 4108247..4108313 | + | 67 | NuclAT_34 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_34 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_34 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_34 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_36 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_36 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_36 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_36 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_38 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_38 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_38 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_38 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_40 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_40 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_40 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_40 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_42 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_42 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_42 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_42 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_44 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_44 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_44 | - | - |
- | 4108247..4108313 | + | 67 | NuclAT_44 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_18 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_18 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_18 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_18 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_21 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_21 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_21 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_21 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_24 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_24 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_24 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_24 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_27 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_27 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_27 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_27 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_30 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_30 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_30 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_30 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_33 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_33 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_33 | - | - |
- | 4108249..4108314 | + | 66 | NuclAT_33 | - | - |
AW869_RS20310 | 4108627..4108734 | - | 108 | WP_000170963.1 | small toxic polypeptide LdrB | - |
- | 4108782..4108849 | + | 68 | NuclAT_17 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_17 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_17 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_17 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_20 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_20 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_20 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_20 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_23 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_23 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_23 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_23 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_26 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_26 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_26 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_26 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_29 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_29 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_29 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_29 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_32 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_32 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_32 | - | - |
- | 4108782..4108849 | + | 68 | NuclAT_32 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_35 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_35 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_35 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_35 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_37 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_37 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_37 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_37 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_39 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_39 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_39 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_39 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_41 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_41 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_41 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_41 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_43 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_43 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_43 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_43 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_45 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_45 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_45 | - | - |
- | 4108783..4108848 | + | 66 | NuclAT_45 | - | - |
AW869_RS20315 | 4109162..4109269 | - | 108 | WP_000170955.1 | small toxic polypeptide LdrA/LdrC | Toxin |
- | 4109317..4109384 | + | 68 | NuclAT_16 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_16 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_16 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_16 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_19 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_19 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_19 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_19 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_22 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_22 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_22 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_22 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_25 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_25 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_25 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_25 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_28 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_28 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_28 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_28 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_31 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_31 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_31 | - | Antitoxin |
- | 4109317..4109384 | + | 68 | NuclAT_31 | - | Antitoxin |
AW869_RS20320 | 4109673..4110773 | - | 1101 | WP_000063607.1 | sodium-potassium/proton antiporter ChaA | - |
AW869_RS20325 | 4111043..4111273 | + | 231 | WP_001146444.1 | putative cation transport regulator ChaB | - |
AW869_RS20330 | 4111431..4112126 | + | 696 | WP_001336325.1 | glutathione-specific gamma-glutamylcyclotransferase | - |
AW869_RS20335 | 4112170..4112523 | - | 354 | WP_001169669.1 | DsrE/F sulfur relay family protein YchN | - |
AW869_RS20340 | 4112708..4114102 | + | 1395 | WP_000086217.1 | inverse autotransporter invasin YchO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 4013.82 Da Isoelectric Point: 11.4779
>T60405 WP_000170955.1 NZ_CP014225:c4109269-4109162 [Escherichia coli str. K-12 substr. MG1655]
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK
MTLAQFAMIFWHDLAAPILAGIITAAIVSWWRNRK
Download Length: 108 bp
>T60405 NZ_CP014225:c4109269-4109162 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 68 bp
>AT60405 NZ_CP014225:4109317-4109384 [Escherichia coli str. K-12 substr. MG1655]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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