Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1802641..1803140 Replicon chromosome
Accession NZ_CP014161
Organism Aerococcus urinae strain CCUG36881

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0X8FG34
Locus tag AWM73_RS08270 Protein ID WP_060778903.1
Coordinates 1802886..1803140 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0X8FFP8
Locus tag AWM73_RS08265 Protein ID WP_060778902.1
Coordinates 1802641..1802886 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM73_RS08240 1798003..1798242 - 240 WP_060778897.1 hypothetical protein -
AWM73_RS08245 1798457..1799647 + 1191 WP_060778898.1 hypothetical protein -
AWM73_RS08250 1799749..1800237 - 489 WP_060778899.1 GNAT family N-acetyltransferase -
AWM73_RS08255 1800388..1801059 + 672 WP_060778900.1 hypothetical protein -
AWM73_RS08260 1801766..1802503 + 738 WP_060778901.1 cyclase family protein -
AWM73_RS08265 1802641..1802886 + 246 WP_060778902.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AWM73_RS08270 1802886..1803140 + 255 WP_060778903.1 Txe/YoeB family addiction module toxin Toxin
AWM73_RS08275 1803240..1804493 - 1254 WP_060778904.1 CoA transferase -
AWM73_RS08280 1804693..1805640 - 948 WP_060778905.1 nitronate monooxygenase family protein -
AWM73_RS08285 1805709..1806494 - 786 WP_060778906.1 enoyl-CoA hydratase/isomerase family protein -
AWM73_RS08290 1806728..1807666 + 939 WP_060778907.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10249.84 Da        Isoelectric Point: 9.9565

>T60319 WP_060778903.1 NZ_CP014161:1802886-1803140 [Aerococcus urinae]
MEVHWSKRAVIERDYWKSHDPKIYDKLYKLLRAIKENPYQGLGKPEPLKYDLSGYWSRRLTQQDRLVYRIKSSAIEVLSC
KYHY

Download         Length: 255 bp

>T60319 NZ_CP014161:1802886-1803140 [Aerococcus urinae]
ATGGAAGTTCATTGGAGTAAGCGGGCGGTAATCGAAAGAGATTACTGGAAGTCCCACGACCCGAAGATTTACGACAAGCT
CTATAAGCTACTAAGGGCGATTAAAGAAAATCCCTACCAGGGTCTAGGCAAGCCCGAGCCTCTTAAATATGACCTGTCTG
GTTACTGGTCCCGCCGATTAACCCAGCAAGATCGCTTAGTCTACCGGATAAAATCATCCGCCATTGAAGTATTATCTTGT
AAATATCATTATTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9532.43 Da        Isoelectric Point: 3.8488

>AT60319 WP_060778902.1 NZ_CP014161:1802641-1802886 [Aerococcus urinae]
MEITNYSDFRQNMKKYMDVINEDSVEYTVTSQNGNDVVVMAKSDFDSLMETYHLLSSRANRENLYQAMEELDQGDYEVEE
I

Download         Length: 246 bp

>AT60319 NZ_CP014161:1802641-1802886 [Aerococcus urinae]
ATGGAAATTACTAATTATAGCGATTTTCGGCAAAATATGAAAAAATACATGGACGTGATCAACGAAGATTCTGTGGAGTA
CACGGTCACTTCTCAAAACGGCAATGATGTGGTGGTGATGGCAAAATCGGATTTTGATAGCTTAATGGAAACCTACCATT
TGCTTTCTAGTCGAGCTAACCGGGAAAACCTCTACCAAGCCATGGAAGAACTCGACCAGGGCGATTATGAAGTTGAGGAG
ATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X8FG34

Antitoxin

Source ID Structure
AlphaFold DB A0A0X8FFP8

References