Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 684379..684895 Replicon chromosome
Accession NZ_CP014161
Organism Aerococcus urinae strain CCUG36881

Toxin (Protein)


Gene name yafQ Uniprot ID A0A109RE66
Locus tag AWM73_RS03100 Protein ID WP_060778045.1
Coordinates 684623..684895 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A109REE1
Locus tag AWM73_RS03095 Protein ID WP_060778044.1
Coordinates 684379..684630 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM73_RS03045 679652..679900 + 249 WP_060778034.1 hypothetical protein -
AWM73_RS03050 679911..680153 + 243 WP_060778035.1 hypothetical protein -
AWM73_RS03055 680165..680407 + 243 WP_060778036.1 hypothetical protein -
AWM73_RS03060 680422..680691 + 270 WP_060778037.1 hypothetical protein -
AWM73_RS03065 680849..681283 + 435 WP_060778038.1 DUF1492 domain-containing protein -
AWM73_RS03070 681305..681670 + 366 WP_060778039.1 hypothetical protein -
AWM73_RS03075 681691..682296 + 606 WP_060778040.1 hypothetical protein -
AWM73_RS03080 682341..682823 + 483 WP_060778041.1 hypothetical protein -
AWM73_RS03085 683581..683775 + 195 WP_060778042.1 hypothetical protein -
AWM73_RS03090 683759..684175 + 417 WP_060778043.1 GTP pyrophosphokinase -
AWM73_RS03095 684379..684630 + 252 WP_060778044.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AWM73_RS03100 684623..684895 + 273 WP_060778045.1 type II toxin-antitoxin system YafQ family toxin Toxin
AWM73_RS03110 685343..685969 - 627 WP_060778046.1 phosphoglycerate mutase family protein -
AWM73_RS03115 686118..688685 + 2568 WP_174519276.1 DNA mismatch repair protein MutS -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 662045..684895 22850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 91 a.a.        Molecular weight: 10744.52 Da        Isoelectric Point: 9.8078

>T60317 WP_060778045.1 NZ_CP014161:684623-684895 [Aerococcus urinae]
MNKIRFTSAFKRDYKRYKKKHYPMTKIDKAICLIASEEIDILINQYRLHNLKGEWQGYKELHVDGDTLIIYIDQKGIVTL
TRLGTHDQLF

Download         Length: 273 bp

>T60317 NZ_CP014161:684623-684895 [Aerococcus urinae]
ATGAATAAAATTAGATTTACTAGTGCTTTCAAGCGGGATTATAAACGTTACAAGAAAAAGCACTATCCCATGACTAAAAT
TGATAAGGCTATATGCTTGATAGCTAGTGAAGAAATAGACATCTTAATTAATCAGTATAGGCTTCATAATCTAAAGGGAG
AATGGCAAGGATATAAAGAACTTCATGTTGATGGGGATACGCTAATTATTTATATTGATCAAAAAGGGATAGTAACCTTA
ACTAGGTTAGGAACACATGACCAACTTTTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.56 Da        Isoelectric Point: 4.2803

>AT60317 WP_060778044.1 NZ_CP014161:684379-684630 [Aerococcus urinae]
MARINIRVDDDLKEQAKATFEDMGLDLTTAITLFIKYSVNSGELPFKPATKKQIENRQARAEAESDQLKTYDNVDDLLEA
LNE

Download         Length: 252 bp

>AT60317 NZ_CP014161:684379-684630 [Aerococcus urinae]
ATGGCTAGAATCAATATTAGAGTTGATGATGATTTAAAAGAGCAAGCTAAAGCAACTTTTGAAGATATGGGGCTTGATCT
GACAACAGCAATCACTTTATTTATTAAGTATTCCGTGAATAGTGGTGAATTACCATTCAAACCAGCAACAAAGAAGCAAA
TTGAGAACAGACAAGCAAGGGCCGAAGCCGAAAGTGACCAACTAAAAACTTATGATAATGTCGATGATTTACTAGAGGCA
TTAAATGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A109RE66


Antitoxin

Source ID Structure
AlphaFold DB A0A109REE1

References