Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-DinJ |
Location | 684379..684895 | Replicon | chromosome |
Accession | NZ_CP014161 | ||
Organism | Aerococcus urinae strain CCUG36881 |
Toxin (Protein)
Gene name | yafQ | Uniprot ID | A0A109RE66 |
Locus tag | AWM73_RS03100 | Protein ID | WP_060778045.1 |
Coordinates | 684623..684895 (+) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | A0A109REE1 |
Locus tag | AWM73_RS03095 | Protein ID | WP_060778044.1 |
Coordinates | 684379..684630 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AWM73_RS03045 | 679652..679900 | + | 249 | WP_060778034.1 | hypothetical protein | - |
AWM73_RS03050 | 679911..680153 | + | 243 | WP_060778035.1 | hypothetical protein | - |
AWM73_RS03055 | 680165..680407 | + | 243 | WP_060778036.1 | hypothetical protein | - |
AWM73_RS03060 | 680422..680691 | + | 270 | WP_060778037.1 | hypothetical protein | - |
AWM73_RS03065 | 680849..681283 | + | 435 | WP_060778038.1 | DUF1492 domain-containing protein | - |
AWM73_RS03070 | 681305..681670 | + | 366 | WP_060778039.1 | hypothetical protein | - |
AWM73_RS03075 | 681691..682296 | + | 606 | WP_060778040.1 | hypothetical protein | - |
AWM73_RS03080 | 682341..682823 | + | 483 | WP_060778041.1 | hypothetical protein | - |
AWM73_RS03085 | 683581..683775 | + | 195 | WP_060778042.1 | hypothetical protein | - |
AWM73_RS03090 | 683759..684175 | + | 417 | WP_060778043.1 | GTP pyrophosphokinase | - |
AWM73_RS03095 | 684379..684630 | + | 252 | WP_060778044.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
AWM73_RS03100 | 684623..684895 | + | 273 | WP_060778045.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
AWM73_RS03110 | 685343..685969 | - | 627 | WP_060778046.1 | phosphoglycerate mutase family protein | - |
AWM73_RS03115 | 686118..688685 | + | 2568 | WP_174519276.1 | DNA mismatch repair protein MutS | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 662045..684895 | 22850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10744.52 Da Isoelectric Point: 9.8078
>T60317 WP_060778045.1 NZ_CP014161:684623-684895 [Aerococcus urinae]
MNKIRFTSAFKRDYKRYKKKHYPMTKIDKAICLIASEEIDILINQYRLHNLKGEWQGYKELHVDGDTLIIYIDQKGIVTL
TRLGTHDQLF
MNKIRFTSAFKRDYKRYKKKHYPMTKIDKAICLIASEEIDILINQYRLHNLKGEWQGYKELHVDGDTLIIYIDQKGIVTL
TRLGTHDQLF
Download Length: 273 bp
>T60317 NZ_CP014161:684623-684895 [Aerococcus urinae]
ATGAATAAAATTAGATTTACTAGTGCTTTCAAGCGGGATTATAAACGTTACAAGAAAAAGCACTATCCCATGACTAAAAT
TGATAAGGCTATATGCTTGATAGCTAGTGAAGAAATAGACATCTTAATTAATCAGTATAGGCTTCATAATCTAAAGGGAG
AATGGCAAGGATATAAAGAACTTCATGTTGATGGGGATACGCTAATTATTTATATTGATCAAAAAGGGATAGTAACCTTA
ACTAGGTTAGGAACACATGACCAACTTTTTTAG
ATGAATAAAATTAGATTTACTAGTGCTTTCAAGCGGGATTATAAACGTTACAAGAAAAAGCACTATCCCATGACTAAAAT
TGATAAGGCTATATGCTTGATAGCTAGTGAAGAAATAGACATCTTAATTAATCAGTATAGGCTTCATAATCTAAAGGGAG
AATGGCAAGGATATAAAGAACTTCATGTTGATGGGGATACGCTAATTATTTATATTGATCAAAAAGGGATAGTAACCTTA
ACTAGGTTAGGAACACATGACCAACTTTTTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9419.56 Da Isoelectric Point: 4.2803
>AT60317 WP_060778044.1 NZ_CP014161:684379-684630 [Aerococcus urinae]
MARINIRVDDDLKEQAKATFEDMGLDLTTAITLFIKYSVNSGELPFKPATKKQIENRQARAEAESDQLKTYDNVDDLLEA
LNE
MARINIRVDDDLKEQAKATFEDMGLDLTTAITLFIKYSVNSGELPFKPATKKQIENRQARAEAESDQLKTYDNVDDLLEA
LNE
Download Length: 252 bp
>AT60317 NZ_CP014161:684379-684630 [Aerococcus urinae]
ATGGCTAGAATCAATATTAGAGTTGATGATGATTTAAAAGAGCAAGCTAAAGCAACTTTTGAAGATATGGGGCTTGATCT
GACAACAGCAATCACTTTATTTATTAAGTATTCCGTGAATAGTGGTGAATTACCATTCAAACCAGCAACAAAGAAGCAAA
TTGAGAACAGACAAGCAAGGGCCGAAGCCGAAAGTGACCAACTAAAAACTTATGATAATGTCGATGATTTACTAGAGGCA
TTAAATGAATAA
ATGGCTAGAATCAATATTAGAGTTGATGATGATTTAAAAGAGCAAGCTAAAGCAACTTTTGAAGATATGGGGCTTGATCT
GACAACAGCAATCACTTTATTTATTAAGTATTCCGTGAATAGTGGTGAATTACCATTCAAACCAGCAACAAAGAAGCAAA
TTGAGAACAGACAAGCAAGGGCCGAAGCCGAAAGTGACCAACTAAAAACTTATGATAATGTCGATGATTTACTAGAGGCA
TTAAATGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A109RE66 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A109REE1 |