Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1434902..1435418 Replicon chromosome
Accession NZ_CP014160
Organism Aerococcus sanguinicola strain CCUG43001

Toxin (Protein)


Gene name yafQ Uniprot ID A0A109RDE0
Locus tag AWM72_RS06340 Protein ID WP_067975013.1
Coordinates 1435146..1435418 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A109RDS4
Locus tag AWM72_RS06335 Protein ID WP_067975011.1
Coordinates 1434902..1435153 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWM72_RS06320 1430004..1430915 + 912 WP_067975003.1 LysR family transcriptional regulator -
AWM72_RS06325 1431081..1433285 + 2205 WP_067975006.1 glycoside hydrolase family 3 C-terminal domain-containing protein -
AWM72_RS06330 1433387..1434649 - 1263 WP_067975008.1 divalent metal cation transporter -
AWM72_RS06335 1434902..1435153 + 252 WP_067975011.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AWM72_RS06340 1435146..1435418 + 273 WP_067975013.1 type II toxin-antitoxin system YafQ family toxin Toxin
AWM72_RS06345 1435710..1436867 - 1158 WP_070486175.1 site-specific integrase -
AWM72_RS06350 1436970..1437914 - 945 WP_067975018.1 helix-turn-helix domain-containing protein -
AWM72_RS06355 1438023..1438238 + 216 WP_067975020.1 helix-turn-helix domain-containing protein -
AWM72_RS06360 1438341..1438547 + 207 WP_067975023.1 hypothetical protein -
AWM72_RS06365 1438560..1438877 + 318 WP_067975029.1 hypothetical protein -
AWM72_RS06370 1438992..1439285 + 294 WP_067975031.1 helix-turn-helix domain-containing protein -
AWM72_RS06375 1439472..1439768 + 297 WP_067975033.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-62)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10852.53 Da        Isoelectric Point: 10.3154

>T60315 WP_067975013.1 NZ_CP014160:1435146-1435418 [Aerococcus sanguinicola]
MTKLQFTSAFKRDYKRYKKKHYPMAKIDQAIRLIARNEINALFNHYRLHDLKGQWRGYKEIHIDGDTLIIYLDREGNITL
TRLGSHDQLF

Download         Length: 273 bp

>T60315 NZ_CP014160:1435146-1435418 [Aerococcus sanguinicola]
ATGACTAAGCTTCAATTTACCAGTGCTTTTAAGCGAGATTATAAACGTTATAAGAAGAAACATTATCCGATGGCAAAAAT
TGATCAGGCTATACGTCTAATTGCCCGCAATGAAATAAATGCTTTATTTAATCACTATCGCTTGCATGATTTAAAGGGGC
AATGGCGAGGCTATAAAGAAATTCATATAGATGGAGATACTTTAATTATCTATCTTGATCGAGAAGGGAATATAACTTTG
ACCAGGCTAGGAAGCCATGATCAATTATTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9406.49 Da        Isoelectric Point: 4.2092

>AT60315 WP_067975011.1 NZ_CP014160:1434902-1435153 [Aerococcus sanguinicola]
MARINMRIDNDLKEQAQETFQEMGLDLTTAITLFIKYSVNSGELPFRPATKKQIENRQARAEAESGSLQSFDNVDDLLEA
LND

Download         Length: 252 bp

>AT60315 NZ_CP014160:1434902-1435153 [Aerococcus sanguinicola]
ATGGCTCGAATTAATATGAGAATTGATAATGACTTAAAGGAACAAGCTCAAGAAACTTTTCAAGAAATGGGATTGGATCT
GACAACAGCGATTACTTTGTTTATTAAGTATTCCGTGAATAGCGGGGAGTTACCTTTTAGGCCTGCAACCAAAAAGCAGA
TTGAGAATAGACAAGCGCGGGCCGAAGCAGAGAGCGGAAGCCTTCAAAGTTTTGACAATGTCGATGATTTGTTAGAGGCT
TTAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109RDE0

Antitoxin

Source ID Structure
AlphaFold DB A0A109RDS4

References