Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1684684..1685345 Replicon chromosome
Accession NZ_CP014158
Organism Pseudomonas citronellolis strain P3B5

Toxin (Protein)


Gene name higB Uniprot ID A0A127MNY7
Locus tag PcP3B5_RS07660 Protein ID WP_061560946.1
Coordinates 1684684..1685031 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A127MNY4
Locus tag PcP3B5_RS07665 Protein ID WP_061560947.1
Coordinates 1685028..1685345 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PcP3B5_RS07645 1680511..1681143 + 633 WP_043267726.1 TRAP transporter small permease -
PcP3B5_RS07650 1681140..1682420 + 1281 WP_061560944.1 C4-dicarboxylate TRAP transporter large permease protein DctM -
PcP3B5_RS07655 1682570..1684525 + 1956 WP_061560945.1 acetate--CoA ligase -
PcP3B5_RS07660 1684684..1685031 + 348 WP_061560946.1 hypothetical protein Toxin
PcP3B5_RS07665 1685028..1685345 + 318 WP_061560947.1 transcriptional regulator Antitoxin
PcP3B5_RS07670 1685800..1686579 + 780 WP_009620740.1 ABC transporter substrate-binding protein -
PcP3B5_RS07675 1687005..1687694 + 690 WP_009620741.1 ABC transporter permease -
PcP3B5_RS07680 1687708..1688406 + 699 WP_043267718.1 ABC transporter permease -
PcP3B5_RS07685 1688423..1689535 + 1113 WP_061560948.1 succinylglutamate desuccinylase/aspartoacylase family protein -
PcP3B5_RS07690 1689551..1690315 + 765 WP_061560949.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-92)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13445.46 Da        Isoelectric Point: 10.3571

>T60303 WP_061560946.1 NZ_CP014158:1684684-1685031 [Pseudomonas citronellolis]
MKATFVELSPFERNRRHYLDDEAFRLFQQLLLARPDAGDVIAGTGGLRKVRFGDPRRGKGRRGGLRVIYYCWLGGAQFWL
FTLYDKDEQDDLNERQRNQLAVLLQAELKLRGMVR

Download         Length: 348 bp

>T60303 NZ_CP014158:1684684-1685031 [Pseudomonas citronellolis]
ATGAAGGCCACATTCGTTGAGCTATCCCCGTTCGAGCGTAATCGCCGTCATTACCTGGATGACGAGGCGTTTCGGTTGTT
CCAGCAGCTTCTGCTGGCACGGCCCGACGCTGGCGACGTGATCGCCGGTACCGGCGGCCTGCGCAAGGTCCGTTTCGGTG
ATCCCAGGCGTGGCAAGGGAAGACGGGGAGGGTTGCGAGTGATCTATTACTGCTGGCTGGGGGGCGCCCAGTTCTGGTTG
TTCACCCTGTACGACAAGGATGAGCAGGATGATCTGAACGAACGGCAGAGAAACCAGTTGGCCGTGCTGCTGCAGGCGGA
ATTGAAATTGAGAGGAATGGTGCGATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11847.67 Da        Isoelectric Point: 6.7289

>AT60303 WP_061560947.1 NZ_CP014158:1685028-1685345 [Pseudomonas citronellolis]
MSKRDIFAELLEGFDDLAAERQGKITLRTHKVESAPLLPATGEEIAALRERLNMSQPVFARILHAAPATLKNWEQNRSRP
NDQATLLIRLLARHPETLDLIIELA

Download         Length: 318 bp

>AT60303 NZ_CP014158:1685028-1685345 [Pseudomonas citronellolis]
ATGAGCAAGCGTGACATCTTTGCCGAGTTGCTGGAGGGCTTCGACGATCTGGCGGCGGAGCGGCAGGGCAAGATCACCCT
GCGAACCCACAAGGTCGAATCGGCGCCACTGCTGCCTGCCACCGGGGAGGAGATAGCTGCCTTGCGCGAACGCCTGAACA
TGTCCCAGCCGGTCTTCGCCCGCATCCTCCATGCCGCACCGGCGACCTTGAAGAACTGGGAGCAGAATCGTTCGCGCCCC
AACGATCAGGCCACCTTGCTGATCCGTCTGTTGGCCAGGCACCCGGAAACCCTGGACTTGATTATCGAGTTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127MNY7

Antitoxin

Source ID Structure
AlphaFold DB A0A127MNY4

References