Detailed information of TA system TA060191

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2230017..2230494
• Replicon: chromosome
• Accession: NZ_CP014113
• Organism: Staphylococcus saprophyticus strain FDAARGOS_168

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: AL528_RS11045
• Protein ID: WP_041080397.1
• Coordinates: 2230017..2230274 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2230326..2230494 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL528_RS13285	2225052..2225129	-	78	WP_115340783.1	hypothetical protein	-
AL528_RS11015	2226204..2226614	-	411	WP_011303346.1	YolD-like family protein	-
AL528_RS11020	2226624..2226815	-	192	WP_011303347.1	hypothetical protein	-
AL528_RS11025	2226911..2227159	-	249	WP_061050614.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
AL528_RS11035	2227752..2228261	-	510	WP_061050616.1	DUF4065 domain-containing protein	-
AL528_RS11040	2228642..2229589	-	948	WP_061050681.1	peptidoglycan recognition protein family protein	-
AL528_RS11045	2230017..2230274	-	258	WP_041080397.1	phage holin	Toxin
-	2230326..2230494	+	169	-	-	Antitoxin
AL528_RS11055	2230675..2230962	-	288	WP_041080395.1	hypothetical protein	-
AL528_RS11060	2230997..2232880	-	1884	WP_061050617.1	glucosaminidase domain-containing protein	-
AL528_RS11065	2232934..2233266	-	333	WP_061050618.1	DUF2977 domain-containing protein	-
AL528_RS11070	2233266..2235131	-	1866	WP_061050619.1	phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2216185..2269687	53502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (6-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9352.18 Da
• Isoelectric Point: 10.2507

>T60191 WP_041080397.1 NZ_CP014113:c2230274-2230017 [Staphylococcus saprophyticus]
MDVKVTVIVRVLGLVLVLVNQCLANKGVSPIPVDESTLMTIAVALITAWKDNPLTNAAKESNKVMKELKTQNKYEKVVMR
SGKEK

Nucleotide

• Length: 258 bp

>T60191 NZ_CP014113:c2230274-2230017 [Staphylococcus saprophyticus]
ATGGATGTAAAAGTAACAGTAATTGTGAGAGTTTTAGGATTGGTTTTGGTATTAGTCAATCAATGCTTAGCAAACAAAGG
TGTTAGTCCAATACCAGTTGATGAGTCAACGTTAATGACAATTGCAGTAGCATTAATTACGGCATGGAAAGATAACCCAC
TTACTAATGCAGCTAAAGAAAGTAATAAAGTAATGAAAGAACTAAAAACACAAAATAAATATGAAAAAGTTGTGATGCGA
AGTGGCAAAGAAAAGTGA

Antitoxin

Nucleotide

• Length: 169 bp

>AT60191 NZ_CP014113:2230326-2230494 [Staphylococcus saprophyticus]
ATTTGATAATATTTTTATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACATATGTGTATCGCCCAAATGAGCCC
GTTAAAAAGACGGTGGCATAGAGATAATTAAATATTAATAAAACCTTTTAACCATCTGCTCGCCAAAGCTATAGATGGTT
ATTTTTTAT

Structures

Antitoxin