Detailed information of TA system TA060170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4056554..4056963
• Replicon: chromosome
• Accession: NZ_CP014111
• Organism: Escherichia coli strain FDAARGOS_144

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3L4RJH9
• Locus tag: AL502_RS21630
• Protein ID: WP_001357525.1
• Coordinates: 4056554..4056892 (-)
• Length: 113 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4056887..4056963 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL502_RS21605	4052210..4053361	-	1152	WP_001298064.1	2-hydroxyacyl-CoA dehydratase subunit D	-
AL502_RS21610	4053479..4054759	-	1281	WP_001523887.1	DUF445 domain-containing protein	-
AL502_RS21615	4054944..4055864	+	921	WP_022296911.1	Rpn family recombination-promoting nuclease/putative transposase	-
AL502_RS21620	4055994..4056170	-	177	WP_001523889.1	GntR family transcriptional regulator	-
AL502_RS21625	4056348..4056512	+	165	WP_001357524.1	DUF1127 domain-containing protein	-
AL502_RS21630	4056554..4056892	-	339	WP_001357525.1	endoribonuclease SymE	Toxin
-	4056887..4056963	+	77	NuclAT_12	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_12	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_12	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_12	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_13	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_13	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_13	-	Antitoxin
-	4056887..4056963	+	77	NuclAT_13	-	Antitoxin
AL502_RS21635	4057107..4057400	-	294	WP_000926091.1	DUF3387 domain-containing protein	-
AL502_RS21640	4057545..4059395	-	1851	WP_000190966.1	AAA family ATPase	-
AL502_RS21645	4059726..4060682	-	957	WP_022296912.1	GTPase	-
AL502_RS21650	4060693..4060896	-	204	WP_000467859.1	YbdD/YjiX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12314.03 Da
• Isoelectric Point: 7.8234

>T60170 WP_001357525.1 NZ_CP014111:c4056892-4056554 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFTTGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQRQVQDFIGVISSKTPR

Nucleotide

• Length: 339 bp

>T60170 NZ_CP014111:c4056892-4056554 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTACCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT60170 NZ_CP014111:4056887-4056963 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3L4RJH9

Antitoxin