Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 39568..40093 Replicon plasmid unnamed1
Accession NZ_CP014110
Organism Escherichia coli strain FDAARGOS_144

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag AL502_RS00360 Protein ID WP_001159871.1
Coordinates 39568..39873 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag AL502_RS00365 Protein ID WP_000813634.1
Coordinates 39875..40093 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL502_RS00330 34835..36105 + 1271 Protein_50 translesion error-prone DNA polymerase V subunit UmuC -
AL502_RS00335 36110..36502 - 393 WP_000340835.1 plasmid partitioning/stability family protein -
AL502_RS00340 36507..37478 - 972 WP_001103694.1 hypothetical protein -
AL502_RS00345 37707..38351 + 645 WP_000633911.1 AAA family ATPase -
AL502_RS00350 38345..38620 + 276 WP_000239529.1 hypothetical protein -
AL502_RS00355 38758..39567 - 810 WP_000016979.1 site-specific integrase -
AL502_RS00360 39568..39873 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
AL502_RS00365 39875..40093 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
AL502_RS00375 41745..43118 - 1374 WP_000244358.1 IS4-like element ISEc13 family transposase -
AL502_RS00385 43973..44614 + 642 WP_000990667.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - senB 1..115764 115764
flank IS/Tn - - 41745..43118 1373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T60143 WP_001159871.1 NZ_CP014110:c39873-39568 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T60143 NZ_CP014110:c39873-39568 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTTCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGACAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGTCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT60143 WP_000813634.1 NZ_CP014110:c40093-39875 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT60143 NZ_CP014110:c40093-39875 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAATTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References