Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1663999..1664183 Replicon chromosome
Accession NZ_CP014064
Organism Staphylococcus aureus strain FDAARGOS_159

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag AL519_RS09170 Protein ID WP_000482652.1
Coordinates 1664076..1664183 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1663999..1664059 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL519_RS09145 1659454..1659621 - 168 Protein_1653 hypothetical protein -
AL519_RS09155 1659852..1661585 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
AL519_RS09160 1661610..1663373 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 1663999..1664059 + 61 - - Antitoxin
AL519_RS09170 1664076..1664183 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
AL519_RS09175 1664317..1664703 - 387 WP_000779360.1 flippase GtxA -
AL519_RS09180 1664971..1666113 + 1143 WP_001176863.1 glycerate kinase -
AL519_RS09185 1666173..1666832 + 660 WP_000831298.1 membrane protein -
AL519_RS09190 1667014..1668225 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
AL519_RS09195 1668348..1668821 - 474 Protein_1661 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T60074 WP_000482652.1 NZ_CP014064:c1664183-1664076 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T60074 NZ_CP014064:c1664183-1664076 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT60074 NZ_CP014064:1663999-1664059 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References