Detailed information of TA system TA060066

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1205131..1205438
• Replicon: chromosome
• Accession: NZ_CP014064
• Organism: Staphylococcus aureus strain FDAARGOS_159

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: AL519_RS06595
• Protein ID: WP_011447039.1
• Coordinates: 1205262..1205438 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1205131..1205270 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL519_RS06535	1200698..1200877	+	180	WP_000669791.1	hypothetical protein	-
AL519_RS06545	1201188..1201448	+	261	WP_001791826.1	hypothetical protein	-
AL519_RS06550	1201501..1201851	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
AL519_RS06555	1202361..1202696	-	336	Protein_1175	SH3 domain-containing protein	-
AL519_RS06575	1203347..1203838	-	492	WP_000920038.1	staphylokinase	-
AL519_RS06580	1204029..1204784	-	756	WP_000861038.1	CHAP domain-containing protein	-
AL519_RS06585	1204796..1205050	-	255	WP_000611512.1	phage holin	-
AL519_RS06590	1205102..1205209	+	108	WP_031762631.1	hypothetical protein	-
-	1205131..1205270	+	140	NuclAT_0	-	Antitoxin
-	1205131..1205270	+	140	NuclAT_0	-	Antitoxin
-	1205131..1205270	+	140	NuclAT_0	-	Antitoxin
-	1205131..1205270	+	140	NuclAT_0	-	Antitoxin
AL519_RS06595	1205262..1205438	-	177	WP_011447039.1	putative holin-like toxin	Toxin
AL519_RS06600	1205641..1206414	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
AL519_RS06605	1206835..1207209	-	375	WP_000340977.1	hypothetical protein	-
AL519_RS06610	1207265..1207552	-	288	WP_001040255.1	hypothetical protein	-
AL519_RS06615	1207599..1207751	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see / hlb / groEL	1201501..1255300	53799

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T60066 WP_011447039.1 NZ_CP014064:c1205438-1205262 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T60066 NZ_CP014064:c1205438-1205262 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT60066 NZ_CP014064:1205131-1205270 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin