Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2629422..2629984 Replicon chromosome
Accession NZ_CP014030
Organism Citrobacter sp. FDAARGOS_156 strain FDAARGOS_155

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AL515_RS12835 Protein ID WP_048212587.1
Coordinates 2629422..2629700 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AL515_RS12840 Protein ID WP_048211649.1
Coordinates 2629700..2629984 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL515_RS12815 2624539..2624970 - 432 WP_048211652.1 peroxiredoxin OsmC -
AL515_RS12820 2625198..2625338 + 141 WP_005126806.1 stationary-phase-induced ribosome-associated protein -
AL515_RS12825 2625518..2627215 + 1698 WP_048211651.1 malate dehydrogenase -
AL515_RS12830 2627525..2629240 + 1716 WP_061067906.1 ATP-binding cassette domain-containing protein -
AL515_RS12835 2629422..2629700 + 279 WP_048212587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL515_RS12840 2629700..2629984 + 285 WP_048211649.1 HigA family addiction module antidote protein Antitoxin
AL515_RS12845 2630028..2630630 - 603 WP_061067907.1 inorganic diphosphatase -
AL515_RS12850 2630759..2631415 - 657 WP_061067908.1 formate dehydrogenase-N subunit gamma -
AL515_RS12855 2631408..2632292 - 885 WP_003833024.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10737.31 Da        Isoelectric Point: 9.9329

>T59969 WP_048212587.1 NZ_CP014030:2629422-2629700 [Citrobacter sp. FDAARGOS_156]
MIMNFRHKGLRDLFLHGRTSGVMAKHVRRLRHRLAVIDAANKVTDINMPGYQLHPLVGERDGRWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T59969 NZ_CP014030:2629422-2629700 [Citrobacter sp. FDAARGOS_156]
ATGATCATGAACTTCAGACACAAGGGATTGCGCGATTTGTTTCTTCATGGACGAACATCAGGCGTTATGGCAAAACATGT
CCGACGATTACGACATAGACTTGCCGTTATTGATGCAGCAAACAAGGTTACAGATATCAATATGCCCGGTTATCAGCTAC
ATCCTTTGGTGGGCGAGCGTGACGGCAGATGGGCAATTTCTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10313.06 Da        Isoelectric Point: 10.0902

>AT59969 WP_048211649.1 NZ_CP014030:2629700-2629984 [Citrobacter sp. FDAARGOS_156]
MKMANHPRPGDIIQEALDELTVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNAWSLAEAK
KNVDISRLRKLAAQ

Download         Length: 285 bp

>AT59969 NZ_CP014030:2629700-2629984 [Citrobacter sp. FDAARGOS_156]
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGACGAACTCACTGTCAGCCTGCGCGAGTT
TGCCAGAGCGATGGAGATTGCACCTTCAACGGCAAGTCGGCTATTAACCGGGAAAGCGGCACTAACGCCTGAGATGGCGA
TTAAACTCTCCGTGGTGATTGGCAGTTCACCCGAAATGTGGTTAAACCTGCAAAATGCCTGGAGCCTGGCAGAGGCCAAA
AAAAACGTGGATATTTCACGCCTGCGTAAGCTGGCAGCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References