Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 693478..694148 Replicon chromosome
Accession NZ_CP014030
Organism Citrobacter sp. FDAARGOS_156 strain FDAARGOS_155

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AL515_RS03355 Protein ID WP_061067044.1
Coordinates 693478..693780 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AL515_RS03360 Protein ID WP_061067045.1
Coordinates 693807..694148 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AL515_RS03335 689021..690544 - 1524 WP_061067042.1 sugar ABC transporter ATP-binding protein -
AL515_RS03345 690659..692923 + 2265 WP_061067043.1 hybrid sensor histidine kinase/response regulator -
AL515_RS03350 692993..693322 + 330 WP_048213892.1 hypothetical protein -
AL515_RS03355 693478..693780 + 303 WP_061067044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AL515_RS03360 693807..694148 + 342 WP_061067045.1 HigA family addiction module antidote protein Antitoxin
AL515_RS03365 694201..694959 - 759 WP_061067046.1 phosphonate metabolism protein PhnP -
AL515_RS03370 694968..695402 - 435 WP_061067047.1 aminoalkylphosphonate N-acetyltransferase -
AL515_RS03375 695389..695943 - 555 WP_061067048.1 ribose 1,5-bisphosphokinase -
AL515_RS03380 695946..697082 - 1137 WP_105242139.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
AL515_RS03385 697079..697759 - 681 WP_061067049.1 phosphonate C-P lyase system protein PhnL -
AL515_RS03390 697769..698527 - 759 WP_003844769.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11793.39 Da        Isoelectric Point: 10.0559

>T59966 WP_061067044.1 NZ_CP014030:693478-693780 [Citrobacter sp. FDAARGOS_156]
MSKSLNIRSFRDTWLEDFFERATSHRKIPADIHTALARKLDIINAAVSHRDLRSPSGNRYEELTGKLQEYSSIRVNKQFR
LIFKWVNGKAEDVYLDPHIY

Download         Length: 303 bp

>T59966 NZ_CP014030:693478-693780 [Citrobacter sp. FDAARGOS_156]
ATGTCTAAATCATTAAATATCAGGAGCTTTCGGGATACATGGCTTGAAGATTTTTTTGAGCGGGCGACATCGCACAGAAA
AATACCAGCGGATATTCATACTGCATTAGCCAGAAAGCTGGATATCATTAATGCGGCTGTTTCGCATCGGGATTTGCGCT
CGCCATCCGGTAACAGATATGAAGAGTTAACCGGAAAATTACAGGAATATTCTTCAATCAGAGTAAACAAGCAGTTCCGA
TTAATATTTAAATGGGTTAACGGTAAGGCCGAAGATGTGTACTTAGATCCACACATCTACTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13159.01 Da        Isoelectric Point: 7.2047

>AT59966 WP_061067045.1 NZ_CP014030:693807-694148 [Citrobacter sp. FDAARGOS_156]
MKQATRKPTTVGDILQYEYLEPLELKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNRESKKVA

Download         Length: 342 bp

>AT59966 NZ_CP014030:693807-694148 [Citrobacter sp. FDAARGOS_156]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGAACTGAAAAT
TAACGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAATCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACTTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATCGCTCAGCGAAATAG
AGAGTCTAAAAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References