Detailed information of TA system TA059926

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3678332..3678984
• Replicon: chromosome
• Accession: NZ_CP014017
• Organism: Serratia liquefaciens strain FDAARGOS_125

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AL485_RS17530
• Protein ID: WP_048760781.1
• Coordinates: 3678640..3678984 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A515CQP0
• Locus tag: AL485_RS17525
• Protein ID: WP_020828411.1
• Coordinates: 3678332..3678634 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL485_RS17505	3673619..3674527	+	909	WP_020828415.1	LysR family transcriptional regulator	-
AL485_RS17510	3674845..3675999	+	1155	WP_048760774.1	MFS transporter	-
AL485_RS17515	3675989..3676912	-	924	WP_048760776.1	LysR family transcriptional regulator	-
AL485_RS17520	3677039..3678301	+	1263	WP_048760779.1	diaminopimelate decarboxylase	-
AL485_RS17525	3678332..3678634	-	303	WP_020828411.1	helix-turn-helix transcriptional regulator	Antitoxin
AL485_RS17530	3678640..3678984	-	345	WP_048760781.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL485_RS17535	3679124..3680134	-	1011	WP_020828409.1	LacI family DNA-binding transcriptional regulator	-
AL485_RS17540	3680286..3680741	+	456	WP_048760784.1	GNAT family N-acetyltransferase	-
AL485_RS17545	3680738..3681757	-	1020	WP_048760787.1	HTH-type transcriptional regulator GalR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13606.74 Da
• Isoelectric Point: 10.6099

>T59926 WP_048760781.1 NZ_CP014017:c3678984-3678640 [Serratia liquefaciens]
MWQIVIVERFDNWFLSLNSDQQKSVLVEIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
VLLCGGDKTGNKRFYQQMLPIAVREFSHYLATQR

Nucleotide

• Length: 345 bp

>T59926 NZ_CP014017:c3678984-3678640 [Serratia liquefaciens]
ATGTGGCAGATCGTGATCGTCGAACGATTCGACAACTGGTTTTTATCATTAAACAGCGATCAACAAAAAAGCGTGCTGGT
AGAAATATTCAAACTGCAGGAGTTCGGCCCCTTGTTGGCGCGTCCTCATGCCGACACGCTGAATCACAAAAACCAAATAC
AGCATCTGAAAGAGTTACGTATTCAGCATCGCGGTCGGCCGTTTCGGATTTTCTTCGCCTTCGATCCGCAACGACAAGCG
GTCCTGCTTTGCGGTGGCGATAAAACCGGTAATAAACGCTTCTATCAACAAATGTTGCCGATCGCCGTCAGAGAGTTTTC
ACATTACTTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11170.02 Da
• Isoelectric Point: 8.6182

>AT59926 WP_020828411.1 NZ_CP014017:c3678634-3678332 [Serratia liquefaciens]
MAKPLSDLIDRLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT59926 NZ_CP014017:c3678634-3678332 [Serratia liquefaciens]
ATGGCCAAACCCTTATCAGATCTGATCGACAGACTCGATCCCACCGTAGTTGAAGCTGCGCAACAGAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCAATGCTTAGGGAAGAACTGGCGGTGTCTCAGGTGGAACTGGCCAAGCGGCTTGGTATCA
GCCAACCTTCGGTCGCCAACCTGGAAAAACGCGGCAGCGAAATTAAACTCTCTTCACTCAAACGCTATATCGAAGCCATG
GGGGGAACGCTGTCGCTGGAAGTTCAGCTCCCGAACGGCCAGCATCGACGGATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A515CQP0