Detailed information of TA system TA059890

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3219321..3219934
• Replicon: chromosome
• Accession: NZ_CP014013
• Organism: Bordetella bronchiseptica strain FDAARGOS_176

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: AL472_RS15415
• Protein ID: WP_003811545.1
• Coordinates: 3219623..3219934 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AL472_RS15410
• Protein ID: WP_003811547.1
• Coordinates: 3219321..3219620 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL472_RS15400	3215430..3216104	-	675	WP_003811550.1	response regulator transcription factor	-
AL472_RS15405	3216273..3219307	+	3035	Protein_3030	autotransporter SphB2	-
AL472_RS15410	3219321..3219620	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
AL472_RS15415	3219623..3219934	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AL472_RS15420	3220048..3220671	-	624	WP_003811542.1	glutathione S-transferase family protein	-
AL472_RS15425	3220790..3221743	-	954	WP_010926624.1	LysR family transcriptional regulator	-
AL472_RS15430	3221859..3222821	+	963	WP_003811538.1	tripartite tricarboxylate transporter substrate binding protein	-
AL472_RS15435	3222836..3224230	+	1395	WP_010926625.1	arylsulfatase	-
AL472_RS15440	3224227..3224814	+	588	WP_010926626.1	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T59890 WP_003811545.1 NZ_CP014013:c3219934-3219623 [Bordetella bronchiseptica]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T59890 NZ_CP014013:c3219934-3219623 [Bordetella bronchiseptica]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAGCTGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT59890 WP_003811547.1 NZ_CP014013:c3219620-3219321 [Bordetella bronchiseptica]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT59890 NZ_CP014013:c3219620-3219321 [Bordetella bronchiseptica]
ATGAAAAAAGACAACACGGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3