Detailed information of TA system TA059887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1815822..1816522
• Replicon: chromosome
• Accession: NZ_CP014013
• Organism: Bordetella bronchiseptica strain FDAARGOS_176

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0H3LPJ8
• Locus tag: AL472_RS08595
• Protein ID: WP_003809515.1
• Coordinates: 1815822..1816118 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: AL472_RS08600
• Protein ID: WP_003809516.1
• Coordinates: 1816121..1816522 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AL472_RS08575	1812118..1812660	+	543	WP_010926149.1	molybdenum cofactor biosysynthesis protein	-
AL472_RS08580	1812836..1813900	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
AL472_RS08585	1813986..1814432	-	447	WP_003809511.1	GFA family protein	-
AL472_RS08590	1814658..1815539	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
AL472_RS08595	1815822..1816118	+	297	WP_003809515.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AL472_RS08600	1816121..1816522	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AL472_RS08605	1816542..1816778	+	237	WP_003809519.1	hypothetical protein	-
AL472_RS08610	1816786..1817265	+	480	WP_003809523.1	disulfide bond formation protein B	-
AL472_RS08615	1817413..1817928	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
AL472_RS08620	1817931..1819121	+	1191	WP_010926150.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
AL472_RS08625	1819141..1820178	+	1038	WP_003809529.1	threonylcarbamoyl-AMP synthase	-
AL472_RS08630	1820315..1821337	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10608.50 Da
• Isoelectric Point: 7.9291

>T59887 WP_003809515.1 NZ_CP014013:1815822-1816118 [Bordetella bronchiseptica]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Nucleotide

• Length: 297 bp

>T59887 NZ_CP014013:1815822-1816118 [Bordetella bronchiseptica]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT59887 WP_003809516.1 NZ_CP014013:1816121-1816522 [Bordetella bronchiseptica]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT59887 NZ_CP014013:1816121-1816522 [Bordetella bronchiseptica]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Toxin

• AlphaFold DB: A0A0H3LPJ8

Antitoxin

• AlphaFold DB: A0A0H3LKS6