Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 161229..161990 Replicon chromosome
Accession NZ_CP013991
Organism Corynebacterium glutamicum strain USDA-ARS-USMARC-56828

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag APT58_RS00780 Protein ID WP_059288430.1
Coordinates 161643..161990 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID A0A0U4XC22
Locus tag APT58_RS00775 Protein ID WP_059288429.1
Coordinates 161229..161570 (-) Length 114 a.a.

Genomic Context

APT58_RS00755APT58_RS00760APT58_RS00765APT58_RS00770APT58_RS15920APT58_RS00790APT58_RS00775APT58_RS00780APT58_RS00785APT58_RS00795APT58_RS00800
Location: 157181..158797 (1617 bp)
Type: Others
Protein ID: WP_081099470.1
Location: 158804..160192 (1389 bp)
Type: Others
Protein ID: WP_059288428.1
Location: 160289..160657 (369 bp)
Type: Others
Protein ID: WP_003857248.1
Location: 160660..160977 (318 bp)
Type: Others
Protein ID: WP_003857246.1
Location: 163069..163215 (147 bp)
Type: Others
Protein ID: WP_172796464.1
Location: 163307..163696 (390 bp)
Type: Others
Protein ID: WP_003857236.1
Location: 161229..161570 (342 bp)
Type: Antitoxin
Protein ID: WP_059288429.1
Location: 161643..161990 (348 bp)
Type: Toxin
Protein ID: WP_059288430.1
Location: 162111..162911 (801 bp)
Type: Others
Protein ID: WP_059288431.1
Location: 163699..164211 (513 bp)
Type: Others
Protein ID: WP_059288432.1
Location: 164251..165762 (1512 bp)
Type: Others
Protein ID: WP_059288433.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
APT58_RS00755157181..158797+1617WP_081099470.1AbgT family transporter-
APT58_RS00760158804..160192+1389WP_059288428.1M20 family metallopeptidase-
APT58_RS00765160289..160657+369WP_003857248.1YidH family protein-
APT58_RS00770160660..160977+318WP_003857246.1DUF202 domain-containing protein-
APT58_RS00775161229..161570-342WP_059288429.1helix-turn-helix transcriptional regulatorAntitoxin
APT58_RS00780161643..161990-348WP_059288430.1type II toxin-antitoxin system RelE/ParE family toxinToxin
APT58_RS00785162111..162911-801WP_059288431.1DeoR/GlpR family DNA-binding transcription regulator-
APT58_RS15920163069..163215+147WP_172796464.1hypothetical protein-
APT58_RS00790163307..163696+390WP_003857236.1VOC family protein-
APT58_RS00795163699..164211-513WP_059288432.1histidine phosphatase family protein-
APT58_RS00800164251..165762-1512WP_059288433.1mannitol dehydrogenase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13543.44 Da        Isoelectric Point: 8.9299

>T59790 WP_059288430.1 NZ_CP013991:c161990-161643 [Corynebacterium glutamicum]
IRTDFIDPWLDPLSDEVYDAVLAAIEHLAEQGPTCGRPFVDTISQSRHKNMKELRPREKSRAKNIRILFAFDPHRHAIFL
VTGDKIDQWNKWYSKNIPIADERFDYHLKQLKKGN

Download         Length: 348 bp

>T59790 NZ_CP013991:c161990-161643 [Corynebacterium glutamicum]
ATTCGAACCGACTTCATTGATCCTTGGCTCGACCCGCTCAGCGACGAAGTTTATGACGCAGTACTTGCCGCCATTGAGCA
CCTTGCCGAGCAGGGGCCGACCTGCGGACGCCCATTCGTAGACACCATCTCACAATCCAGACATAAGAACATGAAAGAGC
TGCGGCCCCGCGAAAAATCACGCGCTAAGAACATCAGGATCTTATTCGCCTTCGATCCCCACCGACATGCAATTTTCTTG
GTCACCGGAGACAAGATCGATCAATGGAATAAGTGGTACAGCAAGAACATACCCATAGCAGATGAAAGATTTGACTACCA
CCTCAAACAACTCAAGAAAGGTAACTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12575.20 Da        Isoelectric Point: 9.6543

>AT59790 WP_059288429.1 NZ_CP013991:c161570-161229 [Corynebacterium glutamicum]
MTSLHDLHRRRPGNRENIDQIKAGMYADAKAHRLRTLREESGLTQESLAKKIGVRQNRISQMEHGHLTSARVSTIQKYVA
ALGGSLELTVKRADGSTVTLPVEEDLEDLADSK

Download         Length: 342 bp

>AT59790 NZ_CP013991:c161570-161229 [Corynebacterium glutamicum]
ATGACTTCACTCCATGACCTTCATCGACGTCGCCCCGGAAATCGCGAAAACATCGATCAGATCAAGGCCGGCATGTACGC
CGATGCAAAGGCCCATCGCCTACGAACCCTCCGCGAAGAGTCTGGCCTCACCCAAGAATCTTTGGCAAAGAAGATCGGGG
TGAGACAGAACCGGATTTCCCAGATGGAGCACGGTCATCTGACCTCAGCCCGAGTATCCACCATTCAAAAGTATGTTGCG
GCTCTCGGTGGCAGCCTTGAACTCACTGTTAAGCGAGCCGACGGAAGTACTGTCACTCTGCCGGTTGAAGAGGATTTAGA
GGACCTGGCAGACTCCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U4XC22

References