Detailed information of TA system TA059790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 161229..161990
• Replicon: chromosome
• Accession: NZ_CP013991
• Organism: Corynebacterium glutamicum strain USDA-ARS-USMARC-56828

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: APT58_RS00780
• Protein ID: WP_059288430.1
• Coordinates: 161643..161990 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: HigA2
• Uniprot ID: A0A0U4XC22
• Locus tag: APT58_RS00775
• Protein ID: WP_059288429.1
• Coordinates: 161229..161570 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APT58_RS00755	157181..158797	+	1617	WP_081099470.1	AbgT family transporter	-
APT58_RS00760	158804..160192	+	1389	WP_059288428.1	M20 family metallopeptidase	-
APT58_RS00765	160289..160657	+	369	WP_003857248.1	YidH family protein	-
APT58_RS00770	160660..160977	+	318	WP_003857246.1	DUF202 domain-containing protein	-
APT58_RS00775	161229..161570	-	342	WP_059288429.1	helix-turn-helix transcriptional regulator	Antitoxin
APT58_RS00780	161643..161990	-	348	WP_059288430.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
APT58_RS00785	162111..162911	-	801	WP_059288431.1	DeoR/GlpR family DNA-binding transcription regulator	-
APT58_RS15920	163069..163215	+	147	WP_172796464.1	hypothetical protein	-
APT58_RS00790	163307..163696	+	390	WP_003857236.1	VOC family protein	-
APT58_RS00795	163699..164211	-	513	WP_059288432.1	histidine phosphatase family protein	-
APT58_RS00800	164251..165762	-	1512	WP_059288433.1	mannitol dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (9-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13543.44 Da
• Isoelectric Point: 8.9299

>T59790 WP_059288430.1 NZ_CP013991:c161990-161643 [Corynebacterium glutamicum]
IRTDFIDPWLDPLSDEVYDAVLAAIEHLAEQGPTCGRPFVDTISQSRHKNMKELRPREKSRAKNIRILFAFDPHRHAIFL
VTGDKIDQWNKWYSKNIPIADERFDYHLKQLKKGN

Nucleotide

• Length: 348 bp

>T59790 NZ_CP013991:c161990-161643 [Corynebacterium glutamicum]
ATTCGAACCGACTTCATTGATCCTTGGCTCGACCCGCTCAGCGACGAAGTTTATGACGCAGTACTTGCCGCCATTGAGCA
CCTTGCCGAGCAGGGGCCGACCTGCGGACGCCCATTCGTAGACACCATCTCACAATCCAGACATAAGAACATGAAAGAGC
TGCGGCCCCGCGAAAAATCACGCGCTAAGAACATCAGGATCTTATTCGCCTTCGATCCCCACCGACATGCAATTTTCTTG
GTCACCGGAGACAAGATCGATCAATGGAATAAGTGGTACAGCAAGAACATACCCATAGCAGATGAAAGATTTGACTACCA
CCTCAAACAACTCAAGAAAGGTAACTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12575.20 Da
• Isoelectric Point: 9.6543

>AT59790 WP_059288429.1 NZ_CP013991:c161570-161229 [Corynebacterium glutamicum]
MTSLHDLHRRRPGNRENIDQIKAGMYADAKAHRLRTLREESGLTQESLAKKIGVRQNRISQMEHGHLTSARVSTIQKYVA
ALGGSLELTVKRADGSTVTLPVEEDLEDLADSK

Nucleotide

• Length: 342 bp

>AT59790 NZ_CP013991:c161570-161229 [Corynebacterium glutamicum]
ATGACTTCACTCCATGACCTTCATCGACGTCGCCCCGGAAATCGCGAAAACATCGATCAGATCAAGGCCGGCATGTACGC
CGATGCAAAGGCCCATCGCCTACGAACCCTCCGCGAAGAGTCTGGCCTCACCCAAGAATCTTTGGCAAAGAAGATCGGGG
TGAGACAGAACCGGATTTCCCAGATGGAGCACGGTCATCTGACCTCAGCCCGAGTATCCACCATTCAAAAGTATGTTGCG
GCTCTCGGTGGCAGCCTTGAACTCACTGTTAAGCGAGCCGACGGAAGTACTGTCACTCTGCCGGTTGAAGAGGATTTAGA
GGACCTGGCAGACTCCAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0U4XC22