Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2725217..2725734 Replicon chromosome
Accession NZ_CP013957
Organism Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag ASL17_RS14190 Protein ID WP_000113262.1
Coordinates 2725217..2725483 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag ASL17_RS14195 Protein ID WP_000584499.1
Coordinates 2725483..2725734 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL17_RS14165 2720643..2721179 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
ASL17_RS14170 2721412..2722236 - 825 WP_000572040.1 formate/nitrite transporter family protein -
ASL17_RS14175 2722453..2722635 - 183 WP_000230294.1 hypothetical protein -
ASL17_RS14180 2722719..2723186 - 468 WP_000153344.1 SRPBCC domain-containing protein -
ASL17_RS14185 2723372..2724922 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
ASL17_RS17095 2725111..2725182 - 72 Protein_2711 hypothetical protein -
ASL17_RS14190 2725217..2725483 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
ASL17_RS14195 2725483..2725734 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASL17_RS14200 2725899..2726000 - 102 WP_001791744.1 hypothetical protein -
ASL17_RS14205 2726007..2726606 - 600 WP_000162813.1 DsbA family protein -
ASL17_RS14210 2726625..2726987 - 363 WP_000819843.1 DUF4467 domain-containing protein -
ASL17_RS14215 2727242..2728493 + 1252 Protein_2717 FemA/FemB family glycyltransferase FmhA -
ASL17_RS14220 2728590..2729321 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
ASL17_RS14225 2729318..2730037 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T59726 WP_000113262.1 NZ_CP013957:c2725483-2725217 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T59726 NZ_CP013957:c2725483-2725217 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT59726 WP_000584499.1 NZ_CP013957:c2725734-2725483 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT59726 NZ_CP013957:c2725734-2725483 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References