Detailed information of TA system TA059715

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2155763..2156062
• Replicon: chromosome
• Accession: NZ_CP013957
• Organism: Staphylococcus aureus strain V521 isolate Sequencing

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: ASL17_RS16685
• Protein ID: WP_072482930.1
• Coordinates: 2155886..2156062 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2155763..2155818 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL17_RS10980	2151321..2151500	+	180	WP_000669789.1	hypothetical protein	-
ASL17_RS10990	2151811..2152071	+	261	WP_001791826.1	hypothetical protein	-
ASL17_RS10995	2152124..2152474	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
ASL17_RS17070	2152984..2153319	-	336	Protein_2092	SH3 domain-containing protein	-
ASL17_RS11005	2153971..2154462	-	492	WP_000920041.1	staphylokinase	-
ASL17_RS11010	2154653..2155408	-	756	WP_000861038.1	CHAP domain-containing protein	-
ASL17_RS11015	2155420..2155674	-	255	WP_000611512.1	phage holin	-
ASL17_RS11020	2155726..2155833	+	108	Protein_2096	hypothetical protein	-
-	2155755..2155894	+	140	NuclAT_0	-	-
-	2155755..2155894	+	140	NuclAT_0	-	-
-	2155755..2155894	+	140	NuclAT_0	-	-
-	2155755..2155894	+	140	NuclAT_0	-	-
-	2155763..2155818	+	56	-	-	Antitoxin
ASL17_RS16685	2155886..2156062	-	177	WP_072482930.1	putative holin-like toxin	Toxin
ASL17_RS11025	2156171..2156944	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
ASL17_RS11030	2157317..2157691	-	375	WP_000340977.1	hypothetical protein	-
ASL17_RS11035	2157747..2158034	-	288	WP_001262621.1	hypothetical protein	-
ASL17_RS11040	2158080..2158232	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2152124..2209649	57525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T59715 WP_072482930.1 NZ_CP013957:c2156062-2155886 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T59715 NZ_CP013957:c2156062-2155886 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT59715 NZ_CP013957:2155763-2155818 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin