Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2595597..2595781 Replicon chromosome
Accession NZ_CP013955
Organism Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag ASL15_RS13180 Protein ID WP_000482652.1
Coordinates 2595674..2595781 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2595597..2595657 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASL15_RS13155 2591052..2591219 - 168 Protein_2508 hypothetical protein -
ASL15_RS13165 2591450..2593183 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
ASL15_RS13170 2593208..2594971 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2595597..2595657 + 61 - - Antitoxin
ASL15_RS13180 2595674..2595781 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
ASL15_RS13185 2595915..2596301 - 387 WP_000779360.1 flippase GtxA -
ASL15_RS13190 2596569..2597711 + 1143 WP_001176863.1 glycerate kinase -
ASL15_RS13195 2597771..2598430 + 660 WP_000831298.1 membrane protein -
ASL15_RS13200 2598612..2599823 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
ASL15_RS13205 2599946..2600419 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T59706 WP_000482652.1 NZ_CP013955:c2595781-2595674 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T59706 NZ_CP013955:c2595781-2595674 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT59706 NZ_CP013955:2595597-2595657 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References