Detailed information of TA system TA059705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2570293..2570810
• Replicon: chromosome
• Accession: NZ_CP013955
• Organism: Staphylococcus aureus strain NCCP14562 isolate Sequencing

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: ASL15_RS13025
• Protein ID: WP_000113265.1
• Coordinates: 2570293..2570559 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: ASL15_RS13030
• Protein ID: WP_000584499.1
• Coordinates: 2570559..2570810 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL15_RS13000	2565721..2566257	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
ASL15_RS13005	2566491..2567315	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
ASL15_RS13010	2567532..2567714	-	183	WP_000230292.1	hypothetical protein	-
ASL15_RS13015	2567798..2568265	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
ASL15_RS13020	2568451..2569998	-	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
ASL15_RS15455	2570187..2570258	-	72	Protein_2483	hypothetical protein	-
ASL15_RS13025	2570293..2570559	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
ASL15_RS13030	2570559..2570810	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ASL15_RS13035	2570975..2571076	-	102	Protein_2486	hypothetical protein	-
ASL15_RS13040	2571083..2571682	-	600	WP_000162810.1	DsbA family protein	-
ASL15_RS13045	2571701..2572063	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
ASL15_RS13050	2572318..2573568	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
ASL15_RS13055	2573665..2574396	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
ASL15_RS13060	2574393..2575112	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T59705 WP_000113265.1 NZ_CP013955:c2570559-2570293 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T59705 NZ_CP013955:c2570559-2570293 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT59705 WP_000584499.1 NZ_CP013955:c2570810-2570559 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT59705 NZ_CP013955:c2570810-2570559 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60