Detailed information of TA system TA059690

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2639428..2639612
• Replicon: chromosome
• Accession: NZ_CP013953
• Organism: Staphylococcus aureus strain NCCP14558 isolate sequencing

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: ASL16_RS13555
• Protein ID: WP_000482652.1
• Coordinates: 2639505..2639612 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2639428..2639488 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL16_RS13530	2634883..2635050	-	168	Protein_2577	hypothetical protein	-
ASL16_RS13540	2635281..2637014	-	1734	WP_000486487.1	ABC transporter ATP-binding protein/permease	-
ASL16_RS13545	2637039..2638802	-	1764	WP_001064825.1	ABC transporter ATP-binding protein/permease	-
-	2639428..2639488	+	61	-	-	Antitoxin
ASL16_RS13555	2639505..2639612	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
ASL16_RS13560	2639746..2640132	-	387	WP_000779360.1	flippase GtxA	-
ASL16_RS13565	2640400..2641542	+	1143	WP_001176863.1	glycerate kinase	-
ASL16_RS13570	2641602..2642261	+	660	WP_000831298.1	membrane protein	-
ASL16_RS13575	2642443..2643654	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
ASL16_RS13580	2643777..2644250	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T59690 WP_000482652.1 NZ_CP013953:c2639612-2639505 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T59690 NZ_CP013953:c2639612-2639505 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT59690 NZ_CP013953:2639428-2639488 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin