Detailed information of TA system TA059677

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1657883..1658462
• Replicon: chromosome
• Accession: NZ_CP013953
• Organism: Staphylococcus aureus strain NCCP14558 isolate sequencing

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: ASL16_RS08185
• Protein ID: WP_001025401.1
• Coordinates: 1658217..1658462 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1657883..1658248 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASL16_RS08145	1654627..1655184	-	558	WP_000645045.1	DUF2815 family protein	-
ASL16_RS08150	1655210..1656376	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
ASL16_RS08155	1656373..1656735	-	363	WP_000279445.1	hypothetical protein	-
ASL16_RS08160	1656750..1657073	-	324	WP_000174995.1	hypothetical protein	-
ASL16_RS08165	1657152..1657313	-	162	WP_015986189.1	DUF1270 family protein	-
ASL16_RS08170	1657325..1657588	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
ASL16_RS08175	1657613..1657828	-	216	WP_001097552.1	hypothetical protein	-
ASL16_RS08180	1657883..1658248	+	366	WP_001128433.1	hypothetical protein	Antitoxin
ASL16_RS08185	1658217..1658462	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
ASL16_RS08190	1658518..1658727	+	210	WP_000642492.1	hypothetical protein	-
ASL16_RS08195	1658717..1658860	-	144	WP_000939498.1	hypothetical protein	-
ASL16_RS08200	1658875..1659318	-	444	WP_000435360.1	hypothetical protein	-
ASL16_RS08205	1659336..1659560	-	225	WP_063653167.1	DUF739 family protein	-
ASL16_RS08210	1659722..1660102	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
ASL16_RS08215	1660124..1660582	+	459	WP_001558059.1	hypothetical protein	-
ASL16_RS08220	1660600..1660921	+	322	Protein_1583	hypothetical protein	-
ASL16_RS08225	1660950..1661345	+	396	WP_000449655.1	hypothetical protein	-
ASL16_RS08230	1661436..1661582	+	147	WP_001795334.1	hypothetical protein	-
ASL16_RS08235	1661579..1662193	-	615	WP_063663496.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1614816..1681149	66333

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T59677 WP_001025401.1 NZ_CP013953:c1658462-1658217 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T59677 NZ_CP013953:c1658462-1658217 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT59677 NZ_CP013953:1657883-1658248 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin