Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2088769..2089334 Replicon chromosome
Accession NZ_CP013940
Organism Cronobacter malonaticus LMG 23826

Toxin (Protein)


Gene name higB Uniprot ID V5U0Z2
Locus tag AFK66_RS09930 Protein ID WP_023898792.1
Coordinates 2089056..2089334 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AFK66_RS09925 Protein ID WP_032968184.1
Coordinates 2088769..2089056 (-) Length 96 a.a.

Genomic Context

AFK66_RS09910AFK66_RS09920AFK66_RS09935AFK66_RS09915AFK66_RS09925AFK66_RS09930AFK66_RS09940AFK66_RS09945
Location: 2084361..2085227 (867 bp)
Type: Others
Protein ID: WP_007774909.1
Location: 2086592..2088709 (2118 bp)
Type: Others
Protein ID: WP_023898790.1
Location: 2089633..2091237 (1605 bp)
Type: Others
Protein ID: WP_007774898.1
Location: 2085256..2086314 (1059 bp)
Type: Others
Protein ID: WP_007774908.1
Location: 2088769..2089056 (288 bp)
Type: Antitoxin
Protein ID: WP_032968184.1
Location: 2089056..2089334 (279 bp)
Type: Toxin
Protein ID: WP_023898792.1
Location: 2091239..2092225 (987 bp)
Type: Others
Protein ID: WP_007774884.1
Location: 2092337..2094271 (1935 bp)
Type: Others
Protein ID: WP_007774882.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFK66_RS099102084361..2085227+867WP_007774909.1ABC transporter permease-
AFK66_RS099152085256..2086314-1059WP_007774908.1YncE family protein-
AFK66_RS099202086592..2088709+2118WP_023898790.1TonB-dependent receptor-
AFK66_RS099252088769..2089056-288WP_032968184.1HigA family addiction module antidote proteinAntitoxin
AFK66_RS099302089056..2089334-279WP_023898792.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AFK66_RS099352089633..2091237+1605WP_007774898.1alpha-amylase family protein-
AFK66_RS099402091239..2092225-987WP_007774884.1SDR family oxidoreductase-
AFK66_RS099452092337..2094271-1935WP_007774882.1HAMP domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10580.05 Da        Isoelectric Point: 10.2970

>T59625 WP_023898792.1 NZ_CP013940:c2089334-2089056 [Cronobacter malonaticus LMG 23826]
MIRSFRHKGLQRYFETGSTAGIHARHARKISLRLAVLNQAIRPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNDEDYH

Download         Length: 279 bp

>T59625 NZ_CP013940:c2089334-2089056 [Cronobacter malonaticus LMG 23826]
ATGATCAGAAGCTTCAGGCATAAAGGCCTGCAACGCTATTTCGAAACGGGTTCCACCGCAGGCATTCATGCCCGCCATGC
CAGAAAGATTTCTCTGCGGCTGGCGGTGCTGAATCAGGCGATAAGACCCGCTGACGTCGACTTACCGGGCTTTTTCCTGC
ATCCCCTGACGGGGGATCGTAAAGGTATATGGGCTGTGACCGTCAGCGGAAACTGGCGCATCACGTTTGAGTTTCGGGAT
GGCGATGTCTTCATCGTCAACGATGAGGATTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10437.04 Da        Isoelectric Point: 8.7963

>AT59625 WP_032968184.1 NZ_CP013940:c2089056-2088769 [Cronobacter malonaticus LMG 23826]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFHA
RQSVDFSHLQRLQRA

Download         Length: 288 bp

>AT59625 NZ_CP013940:c2089056-2088769 [Cronobacter malonaticus LMG 23826]
ATGGCAACGATGTTTAACCCACCACACCCAGGCAGGCTGGTGCAGGAATCAATGGAAGCGCTCGGCCTCAGCGCCCGCGC
GCTGGCCAAAGCGCTGGACGTCGCGCCGTCAACAGTGCAGCGGCTGCTGGTCGGCAAATCTGACGTCTCCCCGGAAATGG
CGCTGCGTCTCTCGGCAGTCCTTGGCAGCTCGCCGCATGTCTGGCTGGGTATGCAGAATGAATACGATCTCTTTCATGCG
CGCCAGTCTGTTGATTTCTCGCATCTGCAACGGTTGCAGAGGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBV5U0Z2

Antitoxin

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Source
ID
Structure
No matching records found

References