Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1357382..1358027 Replicon chromosome
Accession NZ_CP013940
Organism Cronobacter malonaticus LMG 23826

Toxin (Protein)


Gene name higB Uniprot ID A0A423Y0Z1
Locus tag AFK66_RS06315 Protein ID WP_007776379.1
Coordinates 1357382..1357744 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A423Y0X2
Locus tag AFK66_RS06320 Protein ID WP_007776376.1
Coordinates 1357731..1358027 (+) Length 99 a.a.

Genomic Context

AFK66_RS06315AFK66_RS06320AFK66_RS06330AFK66_RS06305AFK66_RS06310AFK66_RS06325
Location: 1357382..1357744 (363 bp)
Type: Toxin
Protein ID: WP_007776379.1
Location: 1357731..1358027 (297 bp)
Type: Antitoxin
Protein ID: WP_007776376.1
Location: 1359525..1360373 (849 bp)
Type: Others
Protein ID: WP_007776367.1
Location: 1352783..1355905 (3123 bp)
Type: Others
Protein ID: WP_023898424.1
Location: 1355905..1357152 (1248 bp)
Type: Others
Protein ID: WP_023898425.1
Location: 1358037..1359389 (1353 bp)
Type: Others
Protein ID: WP_023898428.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AFK66_RS063051352783..1355905-3123WP_023898424.1MdtB/MuxB family multidrug efflux RND transporter permease subunit-
AFK66_RS063101355905..1357152-1248WP_023898425.1MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit-
AFK66_RS063151357382..1357744+363WP_007776379.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AFK66_RS063201357731..1358027+297WP_007776376.1XRE family transcriptional regulatorAntitoxin
AFK66_RS063251358037..1359389-1353WP_023898428.1molecular chaperone-
AFK66_RS063301359525..1360373+849WP_007776367.1DNA-3-methyladenine glycosylase 2-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14303.20 Da        Isoelectric Point: 8.0081

>T59616 WP_007776379.1 NZ_CP013940:1357382-1357744 [Cronobacter malonaticus LMG 23826]
MTWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENY

Download         Length: 363 bp

>T59616 NZ_CP013940:1357382-1357744 [Cronobacter malonaticus LMG 23826]
ATGACATGGACGGTGATTTTTACCGATCGTTTTAACGACTGGTATCAACAGCAGCCCGAAGGATTACAGGATCGTATCGC
TGCGCTCTTATGGAACTTGCGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTCAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTGCGTGTGCAGTATGGCGGCGAACCCTGGCGCGTCTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGTGCAGGCAATAAGCGCAGCCAGAAACATTTTTATGACGCCCTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCAATGGAGAGACGAAATGAAAACTATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT59616 WP_007776376.1 NZ_CP013940:1357731-1358027 [Cronobacter malonaticus LMG 23826]
MKTIDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT59616 NZ_CP013940:1357731-1358027 [Cronobacter malonaticus LMG 23826]
ATGAAAACTATTGATGACGTAATGGCGGGCTTTTCCCCGGAACGGCAGGCTGAAATCCTGCGCATGGCTGACGAAATCGC
GCTGGAACACGGCCTGCCGCGCATTCGCGAAGCGCGGGCGTTTTCGCAGCAGCAGCTGGCGGAGATAATGGGCGTGACGC
AGCCCGCTATCGCCGCCATTGAGCAGCGCGGCAAGGAGATCAAACTGCTGACGCTCAAGCGCTATGTCGAAGCGCTGGGC
GGCAAGCTCTCTTTGCTGATAGAGCTGCCCGAAGGCAGCAAAGTGATCCCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A423Y0Z1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A423Y0X2

References