Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1357382..1358027 Replicon chromosome
Accession NZ_CP013940
Organism Cronobacter malonaticus LMG 23826

Toxin (Protein)


Gene name higB Uniprot ID A0A423Y0Z1
Locus tag AFK66_RS06315 Protein ID WP_007776379.1
Coordinates 1357382..1357744 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A423Y0X2
Locus tag AFK66_RS06320 Protein ID WP_007776376.1
Coordinates 1357731..1358027 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AFK66_RS06305 1352783..1355905 - 3123 WP_023898424.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -
AFK66_RS06310 1355905..1357152 - 1248 WP_023898425.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
AFK66_RS06315 1357382..1357744 + 363 WP_007776379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AFK66_RS06320 1357731..1358027 + 297 WP_007776376.1 XRE family transcriptional regulator Antitoxin
AFK66_RS06325 1358037..1359389 - 1353 WP_023898428.1 molecular chaperone -
AFK66_RS06330 1359525..1360373 + 849 WP_007776367.1 DNA-3-methyladenine glycosylase 2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14303.20 Da        Isoelectric Point: 8.0081

>T59616 WP_007776379.1 NZ_CP013940:1357382-1357744 [Cronobacter malonaticus LMG 23826]
MTWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENY

Download         Length: 363 bp

>T59616 NZ_CP013940:1357382-1357744 [Cronobacter malonaticus LMG 23826]
ATGACATGGACGGTGATTTTTACCGATCGTTTTAACGACTGGTATCAACAGCAGCCCGAAGGATTACAGGATCGTATCGC
TGCGCTCTTATGGAACTTGCGTTATTCCGGCCCGCTTGTCGGACGCCCGCTGGTCGATACGGTCAAAGGTTCGCGTTATC
CCAACCTGAAAGAGCTGCGTGTGCAGTATGGCGGCGAACCCTGGCGCGTCTTTTTTGCGTTTGACGCTGAACGTCAGGCC
GTTGTGCTCTGTGCAGGCAATAAGCGCAGCCAGAAACATTTTTATGACGCCCTAATCAGGCAGGCTGAAGAAGAATTCTT
CCTGCATGTGCAAGCAATGGAGAGACGAAATGAAAACTATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT59616 WP_007776376.1 NZ_CP013940:1357731-1358027 [Cronobacter malonaticus LMG 23826]
MKTIDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp

>AT59616 NZ_CP013940:1357731-1358027 [Cronobacter malonaticus LMG 23826]
ATGAAAACTATTGATGACGTAATGGCGGGCTTTTCCCCGGAACGGCAGGCTGAAATCCTGCGCATGGCTGACGAAATCGC
GCTGGAACACGGCCTGCCGCGCATTCGCGAAGCGCGGGCGTTTTCGCAGCAGCAGCTGGCGGAGATAATGGGCGTGACGC
AGCCCGCTATCGCCGCCATTGAGCAGCGCGGCAAGGAGATCAAACTGCTGACGCTCAAGCGCTATGTCGAAGCGCTGGGC
GGCAAGCTCTCTTTGCTGATAGAGCTGCCCGAAGGCAGCAAAGTGATCCCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A423Y0Z1

Antitoxin

Source ID Structure
AlphaFold DB A0A423Y0X2

References