Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1162703..1163267 Replicon chromosome
Accession NZ_CP013921
Organism Lacticaseibacillus paracasei strain KL1

Toxin (Protein)


Gene name yafQ Uniprot ID C2FG57
Locus tag AWC33_RS05595 Protein ID WP_003661092.1
Coordinates 1162703..1163005 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A8E0I752
Locus tag AWC33_RS05600 Protein ID WP_016365698.1
Coordinates 1162998..1163267 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AWC33_RS05580 1158386..1158823 + 438 WP_003661085.1 hypothetical protein -
AWC33_RS05585 1158998..1161175 - 2178 WP_016383421.1 RNA-binding transcriptional accessory protein -
AWC33_RS05590 1161411..1162103 - 693 WP_003661089.1 hypothetical protein -
AWC33_RS05595 1162703..1163005 - 303 WP_003661092.1 type II toxin-antitoxin system YafQ family toxin Toxin
AWC33_RS05600 1162998..1163267 - 270 WP_016365698.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AWC33_RS05605 1163641..1164294 - 654 WP_003570049.1 GNAT family N-acetyltransferase -
AWC33_RS05610 1164339..1165154 - 816 WP_003661098.1 DUF2399 domain-containing protein -
AWC33_RS14775 1165179..1165802 - 624 WP_079351422.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11383.23 Da        Isoelectric Point: 10.4225

>T59576 WP_003661092.1 NZ_CP013921:c1163005-1162703 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGGWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T59576 NZ_CP013921:c1163005-1162703 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCTGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCTT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGGCTGGTTGCTAATCTATAAAATTAAG
CAGCAAGATCTTATTTTAACCCTAGTTAGAACCGGATCTCATCATAACCTTCTGGGTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9996.71 Da        Isoelectric Point: 7.2026

>AT59576 WP_016365698.1 NZ_CP013921:c1163267-1162998 [Lacticaseibacillus paracasei]
MAATKKETRLNIRIDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT59576 NZ_CP013921:c1163267-1162998 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTATTGATCCTGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACGATGTTCATGACGAAAATGGTGAAGGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACACCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References