Detailed information of TA system TA059492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1615834..1616489
• Replicon: chromosome
• Accession: NZ_CP013872
• Organism: Bordetella pertussis strain F778

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: AVS45_RS07900
• Protein ID: WP_047122780.1
• Coordinates: 1615834..1616085 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: AVS45_RS07905
• Protein ID: WP_003809516.1
• Coordinates: 1616088..1616489 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVS45_RS07875	1610995..1612125	-	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-
AVS45_RS07880	1612360..1612941	+	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
AVS45_RS07885	1613078..1614142	+	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
AVS45_RS07890	1614227..1614673	-	447	WP_003819827.1	GFA family protein	-
AVS45_RS07895	1614898..1615779	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
AVS45_RS07900	1615834..1616085	+	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
AVS45_RS07905	1616088..1616489	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
AVS45_RS07910	1616509..1616745	+	237	WP_010930404.1	membrane protein	-
AVS45_RS07915	1616753..1617232	+	480	WP_010930405.1	disulfide bond formation protein B	-
AVS45_RS07920	1617382..1617897	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
AVS45_RS07925	1617900..1619090	+	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
AVS45_RS07930	1619110..1620147	+	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
AVS45_RS07935	1620284..1621306	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T59492 WP_047122780.1 NZ_CP013872:1615834-1616085 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T59492 NZ_CP013872:1615834-1616085 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT59492 WP_003809516.1 NZ_CP013872:1616088-1616489 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT59492 NZ_CP013872:1616088-1616489 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6