Detailed information of TA system TA059441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1387352..1387573
• Replicon: chromosome
• Accession: NZ_CP013835
• Organism: Escherichia coli strain JJ2434

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A1U9U3P9
• Locus tag: AVR68_RS08150
• Protein ID: WP_001531632.1
• Coordinates: 1387352..1387459 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1387507..1387573 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVR68_RS08125	1383196..1384278	+	1083	WP_000804726.1	peptide chain release factor 1	-
AVR68_RS08130	1384278..1385111	+	834	WP_000456450.1	peptide chain release factor N(5)-glutamine methyltransferase	-
AVR68_RS08135	1385108..1385500	+	393	WP_000200375.1	invasion regulator SirB2	-
AVR68_RS08140	1385504..1386313	+	810	WP_001257044.1	invasion regulator SirB1	-
AVR68_RS08145	1386349..1387203	+	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
AVR68_RS08150	1387352..1387459	-	108	WP_001531632.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	1387507..1387573	+	67	NuclAT_10	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_10	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_10	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_10	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_5	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_5	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_5	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_5	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_6	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_6	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_6	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_6	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_7	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_7	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_7	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_7	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_8	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_8	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_8	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_8	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_9	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_9	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_9	-	Antitoxin
-	1387507..1387573	+	67	NuclAT_9	-	Antitoxin
-	1387509..1387572	+	64	NuclAT_12	-	-
-	1387509..1387572	+	64	NuclAT_12	-	-
-	1387509..1387572	+	64	NuclAT_12	-	-
-	1387509..1387572	+	64	NuclAT_12	-	-
-	1387509..1387572	+	64	NuclAT_13	-	-
-	1387509..1387572	+	64	NuclAT_13	-	-
-	1387509..1387572	+	64	NuclAT_13	-	-
-	1387509..1387572	+	64	NuclAT_13	-	-
-	1387509..1387572	+	64	NuclAT_14	-	-
-	1387509..1387572	+	64	NuclAT_14	-	-
-	1387509..1387572	+	64	NuclAT_14	-	-
-	1387509..1387572	+	64	NuclAT_14	-	-
-	1387509..1387572	+	64	NuclAT_15	-	-
-	1387509..1387572	+	64	NuclAT_15	-	-
-	1387509..1387572	+	64	NuclAT_15	-	-
-	1387509..1387572	+	64	NuclAT_15	-	-
-	1387509..1387572	+	64	NuclAT_16	-	-
-	1387509..1387572	+	64	NuclAT_16	-	-
-	1387509..1387572	+	64	NuclAT_16	-	-
-	1387509..1387572	+	64	NuclAT_16	-	-
-	1387509..1387572	+	64	NuclAT_17	-	-
-	1387509..1387572	+	64	NuclAT_17	-	-
-	1387509..1387572	+	64	NuclAT_17	-	-
-	1387509..1387572	+	64	NuclAT_17	-	-
-	1387509..1387574	+	66	NuclAT_18	-	-
-	1387509..1387574	+	66	NuclAT_18	-	-
-	1387509..1387574	+	66	NuclAT_18	-	-
-	1387509..1387574	+	66	NuclAT_18	-	-
-	1387509..1387574	+	66	NuclAT_19	-	-
-	1387509..1387574	+	66	NuclAT_19	-	-
-	1387509..1387574	+	66	NuclAT_19	-	-
-	1387509..1387574	+	66	NuclAT_19	-	-
-	1387509..1387574	+	66	NuclAT_20	-	-
-	1387509..1387574	+	66	NuclAT_20	-	-
-	1387509..1387574	+	66	NuclAT_20	-	-
-	1387509..1387574	+	66	NuclAT_20	-	-
-	1387509..1387574	+	66	NuclAT_21	-	-
-	1387509..1387574	+	66	NuclAT_21	-	-
-	1387509..1387574	+	66	NuclAT_21	-	-
-	1387509..1387574	+	66	NuclAT_21	-	-
-	1387509..1387574	+	66	NuclAT_22	-	-
-	1387509..1387574	+	66	NuclAT_22	-	-
-	1387509..1387574	+	66	NuclAT_22	-	-
-	1387509..1387574	+	66	NuclAT_22	-	-
-	1387509..1387574	+	66	NuclAT_23	-	-
-	1387509..1387574	+	66	NuclAT_23	-	-
-	1387509..1387574	+	66	NuclAT_23	-	-
-	1387509..1387574	+	66	NuclAT_23	-	-
AVR68_RS08155	1387864..1388964	-	1101	WP_000063608.1	sodium-potassium/proton antiporter ChaA	-
AVR68_RS08160	1389234..1389473	+	240	WP_000120702.1	putative cation transport regulator ChaB	-
AVR68_RS08165	1389622..1390317	+	696	WP_001295621.1	glutathione-specific gamma-glutamylcyclotransferase	-
AVR68_RS08170	1390361..1390714	-	354	WP_001169659.1	DsrE/F sulfur relay family protein YchN	-
AVR68_RS08175	1390899..1392293	+	1395	WP_000086187.1	inverse autotransporter invasin YchO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4040.89 Da
• Isoelectric Point: 12.5163

>T59441 WP_001531632.1 NZ_CP013835:c1387459-1387352 [Escherichia coli]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Nucleotide

• Length: 108 bp

>T59441 NZ_CP013835:c1387459-1387352 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT59441 NZ_CP013835:1387507-1387573 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A1U9U3P9

Antitoxin