Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 117128..117664 Replicon plasmid p4PS10
Accession NZ_CP013820
Organism Piscirickettsia salmonis strain AY3800B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag AVM72_RS17235 Protein ID WP_036772441.1
Coordinates 117392..117664 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVM72_RS17230 Protein ID WP_032126795.1
Coordinates 117128..117388 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVM72_RS17205 113479..114606 + 1128 WP_036772450.1 hypothetical protein -
AVM72_RS17210 114686..114949 + 264 Protein_147 IS6 family transposase -
AVM72_RS17215 115338..115769 + 432 Protein_148 IS6 family transposase -
AVM72_RS17220 115772..116338 - 567 Protein_149 IS6 family transposase -
AVM72_RS20415 116624..116788 - 165 Protein_150 IS6 family transposase -
AVM72_RS17230 117128..117388 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVM72_RS17235 117392..117664 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
AVM72_RS17240 117740..118468 + 729 WP_017375910.1 IS6 family transposase -
AVM72_RS17245 119038..120102 - 1065 WP_174872554.1 IS91 family transposase -
AVM72_RS21085 120282..120461 - 180 WP_157894752.1 hypothetical protein -
AVM72_RS17255 120874..121701 + 828 WP_048876208.1 IS30 family transposase -
AVM72_RS17260 121744..122473 - 730 Protein_157 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188301 188301
- inside IScluster/Tn - - 97499..128087 30588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T59375 WP_036772441.1 NZ_CP013820:117392-117664 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T59375 NZ_CP013820:117392-117664 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59375 WP_032126795.1 NZ_CP013820:117128-117388 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59375 NZ_CP013820:117128-117388 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References