Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 7939..8475 Replicon plasmid p1PS13
Accession NZ_CP013802
Organism Piscirickettsia salmonis strain PM22180B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVM70_RS16255 Protein ID WP_016211910.1
Coordinates 7939..8211 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVM70_RS16260 Protein ID WP_032126795.1
Coordinates 8215..8475 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVM70_RS19660 3868..4125 - 258 WP_098082828.1 transposase -
AVM70_RS16225 4358..5275 + 918 Protein_6 IS30 family transposase -
AVM70_RS16230 5392..5856 + 465 WP_036774631.1 hypothetical protein -
AVM70_RS16235 5915..6055 - 141 Protein_8 helix-turn-helix domain-containing protein -
AVM70_RS16240 6219..6365 + 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
AVM70_RS16245 7082..7222 - 141 Protein_10 helix-turn-helix domain-containing protein -
AVM70_RS16250 7395..7613 + 219 WP_155046644.1 hypothetical protein -
AVM70_RS16255 7939..8211 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVM70_RS16260 8215..8475 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVM70_RS16265 8748..9338 + 591 WP_027242600.1 site-specific integrase -
AVM70_RS16270 9366..10769 - 1404 WP_048876031.1 IS4 family transposase -
AVM70_RS18560 11473..12318 - 846 Protein_16 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..57431 57431
- flank IS/Tn - - 11801..11995 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59355 WP_016211910.1 NZ_CP013802:c8211-7939 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59355 NZ_CP013802:c8211-7939 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59355 WP_032126795.1 NZ_CP013802:c8475-8215 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59355 NZ_CP013802:c8475-8215 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References