Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 50093..50629 Replicon plasmid p2PS9
Accession NZ_CP013798
Organism Piscirickettsia salmonis strain AY6532B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI56_RS17785 Protein ID WP_016211910.1
Coordinates 50093..50365 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI56_RS17790 Protein ID WP_032126795.1
Coordinates 50369..50629 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI56_RS19865 45849..46022 - 174 WP_155764056.1 hypothetical protein -
AVI56_RS19870 46022..46279 - 258 WP_098082828.1 transposase -
AVI56_RS17755 46512..47429 + 918 Protein_51 IS30 family transposase -
AVI56_RS17760 47546..48010 + 465 WP_036774631.1 hypothetical protein -
AVI56_RS17765 48069..48209 - 141 Protein_53 helix-turn-helix domain-containing protein -
AVI56_RS17770 48373..48519 + 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
AVI56_RS17775 49236..49376 - 141 Protein_55 helix-turn-helix domain-containing protein -
AVI56_RS17780 49549..49767 + 219 WP_155046644.1 hypothetical protein -
AVI56_RS17785 50093..50365 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI56_RS17790 50369..50629 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI56_RS17795 50902..51492 + 591 WP_027242600.1 site-specific integrase -
AVI56_RS17800 51520..52923 - 1404 WP_048876031.1 IS4 family transposase -
AVI56_RS18640 53627..54472 - 846 Protein_61 IS982 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60078 60078
- flank IS/Tn - - 53955..54149 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59352 WP_016211910.1 NZ_CP013798:c50365-50093 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59352 NZ_CP013798:c50365-50093 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59352 WP_032126795.1 NZ_CP013798:c50629-50369 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59352 NZ_CP013798:c50629-50369 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References