Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 53314..53850 Replicon plasmid p2PS8
Accession NZ_CP013793
Organism Piscirickettsia salmonis strain AY6297B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI55_RS17540 Protein ID WP_016211910.1
Coordinates 53578..53850 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI55_RS17535 Protein ID WP_032126795.1
Coordinates 53314..53574 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI55_RS17515 49471..50316 + 846 Protein_52 IS982 family transposase -
AVI55_RS17525 51020..52423 + 1404 WP_048876031.1 IS4 family transposase -
AVI55_RS17530 52451..53041 - 591 WP_027242600.1 site-specific integrase -
AVI55_RS17535 53314..53574 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI55_RS17540 53578..53850 + 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI55_RS17545 54176..54394 - 219 WP_155046644.1 hypothetical protein -
AVI55_RS17550 54567..54707 + 141 Protein_58 helix-turn-helix domain-containing protein -
AVI55_RS17555 55424..55570 - 147 WP_157894761.1 transposase zinc-binding domain-containing protein -
AVI55_RS17560 55734..55874 + 141 Protein_60 helix-turn-helix domain-containing protein -
AVI55_RS17565 55933..56397 - 465 WP_036774631.1 hypothetical protein -
AVI55_RS17570 56514..57431 - 918 Protein_62 IS30 family transposase -
AVI55_RS19265 57664..57921 + 258 WP_098082828.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..60081 60081
- flank IS/Tn - - 49794..49988 194


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59346 WP_016211910.1 NZ_CP013793:53578-53850 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59346 NZ_CP013793:53578-53850 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59346 WP_032126795.1 NZ_CP013793:53314-53574 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59346 NZ_CP013793:53314-53574 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References