Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 117096..117632 Replicon plasmid p1PS8
Accession NZ_CP013792
Organism Piscirickettsia salmonis strain AY6297B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1L6THY5
Locus tag AVI55_RS16805 Protein ID WP_036772441.1
Coordinates 117360..117632 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI55_RS16800 Protein ID WP_032126795.1
Coordinates 117096..117356 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI55_RS16780 113447..114574 + 1128 WP_036772450.1 hypothetical protein -
AVI55_RS16785 114654..114917 + 264 Protein_150 IS6 family transposase -
AVI55_RS16790 115306..115737 + 432 Protein_151 IS6 family transposase -
AVI55_RS16795 115740..116306 - 567 Protein_152 IS6 family transposase -
AVI55_RS19205 116592..116756 - 165 Protein_153 IS6 family transposase -
AVI55_RS16800 117096..117356 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI55_RS16805 117360..117632 + 273 WP_036772441.1 Txe/YoeB family addiction module toxin Toxin
AVI55_RS16810 117708..118436 + 729 WP_017375910.1 IS6 family transposase -
AVI55_RS16815 119005..120069 - 1065 WP_174872554.1 IS91 family transposase -
AVI55_RS19975 120249..120428 - 180 WP_157894752.1 hypothetical protein -
AVI55_RS16830 120841..121668 + 828 WP_048876208.1 IS30 family transposase -
AVI55_RS16835 121711..122440 - 730 Protein_160 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188268 188268
- inside IScluster/Tn - - 97467..128054 30587


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10785.31 Da        Isoelectric Point: 7.8926

>T59343 WP_036772441.1 NZ_CP013792:117360-117632 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRMPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
ISACRYHYDQ

Download         Length: 273 bp

>T59343 NZ_CP013792:117360-117632 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
GCTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCATGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTTCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59343 WP_032126795.1 NZ_CP013792:117096-117356 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59343 NZ_CP013792:117096-117356 [Piscirickettsia salmonis]
ATGCTACGAGATAACATCAATGCTACGGCAGCACGGGATAATTTTAAGAGTACCTGTGATACAGTGTGTGAAAACAATGC
TCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGTATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6THY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References