Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 159972..160508 Replicon plasmid p1PS5
Accession NZ_CP013779
Organism Piscirickettsia salmonis strain PM51819A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI52_RS17370 Protein ID WP_016211910.1
Coordinates 159972..160244 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI52_RS17375 Protein ID WP_032126795.1
Coordinates 160248..160508 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI52_RS17335 155582..156184 - 603 Protein_214 IS30 family transposase -
AVI52_RS17340 156244..156537 + 294 WP_032126637.1 transposase -
AVI52_RS18850 156654..156983 + 330 WP_081377914.1 IS3 family transposase -
AVI52_RS17355 157128..157685 + 558 WP_081377915.1 IS3 family transposase -
AVI52_RS17360 157694..158092 - 399 WP_075273786.1 helix-turn-helix domain-containing protein -
AVI52_RS17365 158525..159646 + 1122 WP_016211913.1 hypothetical protein -
AVI52_RS17370 159972..160244 - 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI52_RS17375 160248..160508 - 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI52_RS17380 160781..161370 + 590 Protein_222 site-specific integrase -
AVI52_RS17385 161460..162172 + 713 Protein_223 IS6 family transposase -
AVI52_RS17390 162110..162466 - 357 WP_075275161.1 IS3 family transposase -
AVI52_RS17395 162671..163351 - 681 Protein_225 IS3 family transposase -
AVI52_RS19830 163462..163605 - 144 WP_155764128.1 hypothetical protein -
AVI52_RS17400 163793..164137 - 345 WP_081377917.1 Clp protease ClpP -
AVI52_RS17405 164435..164710 + 276 WP_075275163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165427 165427
- flank IS/Tn - - 161822..162172 350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59327 WP_016211910.1 NZ_CP013779:c160244-159972 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59327 NZ_CP013779:c160244-159972 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59327 WP_032126795.1 NZ_CP013779:c160508-160248 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59327 NZ_CP013779:c160508-160248 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References