Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 63425..63961 Replicon plasmid p1PS3
Accession NZ_CP013769
Organism Piscirickettsia salmonis strain PM23019A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6I5YBD1
Locus tag AVI50_RS16110 Protein ID WP_016211910.1
Coordinates 63689..63961 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B8U9U2
Locus tag AVI50_RS16105 Protein ID WP_032126795.1
Coordinates 63425..63685 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI50_RS16070 58558..59034 + 477 WP_051307374.1 Clp protease ClpP -
AVI50_RS16080 59149..60302 + 1154 WP_155047011.1 IS3 family transposase -
AVI50_RS16085 60311..61018 - 708 WP_075273780.1 IS6 family transposase -
AVI50_RS16090 61157..62128 - 972 WP_033923677.1 IS91 family transposase -
AVI50_RS17945 62053..62292 - 240 WP_075275277.1 transposase zinc-binding domain-containing protein -
AVI50_RS16100 62562..63152 - 591 WP_016211912.1 site-specific integrase -
AVI50_RS16105 63425..63685 + 261 WP_032126795.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AVI50_RS16110 63689..63961 + 273 WP_016211910.1 Txe/YoeB family addiction module toxin Toxin
AVI50_RS16115 64287..65408 - 1122 WP_016211913.1 hypothetical protein -
AVI50_RS16120 65841..66239 + 399 WP_075273786.1 helix-turn-helix domain-containing protein -
AVI50_RS16135 67461..68063 + 603 Protein_93 IS30 family transposase -
AVI50_RS16140 68400..68774 + 375 WP_016212499.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..153216 153216
- flank IS/Tn - - 60311..61018 707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-74)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10739.22 Da        Isoelectric Point: 7.8926

>T59318 WP_016211910.1 NZ_CP013769:63689-63961 [Piscirickettsia salmonis]
MSKLNLLTWSDDAWDDYLYWQDTDKKVLKKINKLIKECQRTPTEGIGHPEPLKHDFSGYWSRKIKGEHRLVYSFDATSLM
IAACRYHYDQ

Download         Length: 273 bp

>T59318 NZ_CP013769:63689-63961 [Piscirickettsia salmonis]
TTGTCAAAACTAAACTTACTTACTTGGAGTGATGATGCTTGGGATGATTACCTTTATTGGCAAGATACAGATAAAAAGGT
ACTTAAAAAAATCAATAAACTTATAAAGGAATGTCAACGCACGCCGACAGAAGGTATTGGTCATCCCGAACCTTTAAAAC
ATGATTTCAGTGGCTATTGGAGCCGAAAAATAAAGGGTGAGCATAGATTAGTTTATTCATTTGATGCGACCAGTTTAATG
ATTGCTGCATGCCGTTACCATTATGATCAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9555.93 Da        Isoelectric Point: 5.1167

>AT59318 WP_032126795.1 NZ_CP013769:63425-63685 [Piscirickettsia salmonis]
MLRDNINATAARDNFKSTCDTVCENNAPVLVKRKGAEDVVIISASDFGGMEETIHLLSSRIMATRLMRSMKQLDEGKGVQ
RDIIEE

Download         Length: 261 bp

>AT59318 NZ_CP013769:63425-63685 [Piscirickettsia salmonis]
ATGTTACGAGACAACATTAATGCTACGGCAGCGCGGGATAATTTTAAGAGTACCTGTGATACGGTGTGTGAAAACAATGC
CCCTGTACTTGTGAAGCGCAAGGGTGCTGAGGATGTCGTTATTATTTCTGCTTCTGACTTTGGTGGTATGGAAGAAACGA
TCCACTTATTAAGTAGTAGAATAATGGCAACACGCCTTATGAGAAGCATGAAACAACTTGATGAAGGTAAAGGTGTTCAA
CGTGATATTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5YBD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0B8U9U2

References